高级搜索

肿瘤长度、最大横径和体积对临床N0期食管鳞癌患者预后的影响

高红梅, 肖国伟, 池书平, 沈文斌

高红梅, 肖国伟, 池书平, 沈文斌. 肿瘤长度、最大横径和体积对临床N0期食管鳞癌患者预后的影响[J]. 肿瘤防治研究, 2015, 42(08): 777-781. DOI: 10.3971/j.issn.1000-8578.2015.08.006
引用本文: 高红梅, 肖国伟, 池书平, 沈文斌. 肿瘤长度、最大横径和体积对临床N0期食管鳞癌患者预后的影响[J]. 肿瘤防治研究, 2015, 42(08): 777-781. DOI: 10.3971/j.issn.1000-8578.2015.08.006
GAO Hongmei, XIAO Guowei, CHI Shuping, SHEN Wenbin. Effect of Tumor Length, Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(08): 777-781. DOI: 10.3971/j.issn.1000-8578.2015.08.006
Citation: GAO Hongmei, XIAO Guowei, CHI Shuping, SHEN Wenbin. Effect of Tumor Length, Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(08): 777-781. DOI: 10.3971/j.issn.1000-8578.2015.08.006

肿瘤长度、最大横径和体积对临床N0期食管鳞癌患者预后的影响

详细信息
    作者简介:

    高红梅(1979-),女,硕士,主治医师,主要从事肿瘤影像诊断研究

    通讯作者:

    沈文斌,E-mail:wbshen1979@sina.com

  • 中图分类号: R735.1

Effect of Tumor Length, Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients

  • 摘要: 目的 探讨临床无转移食管鳞癌的肿瘤局部因素对患者预后的影响情况。方法 回顾性分析符合入组条件的263例N0期食管鳞癌患者,对患者的食管钡餐造影病变长度、GTV最大横径、GTV长度及GTV体积等肿瘤局部因素对患者预后的影响情况进行分析。结果 ROC曲线分析结果显示食管钡餐造影病变长度、GTV最大横径、GTV长度及GTV体积预测患者预后的临界值分别为4.25、1.80、5.85 cm和27.98 cm3。单因素分析结果显示:食管钡餐造影病变长度(P=0.0004)、GTV最大横径(P=0.0246)、GTV长度(P=0.0035)及GTV体积(P=0.0184)均为患者生存率的预后影响因素;食管钡餐造影病变长度(P=0.0149)为患者局部控制率的影响因素。多因素分析结果显示:食管钡餐造影病变长度(P=0.0013)、GTV最大横径(P=0.0047)及GTV长度(P=0.0032)为患者生存率的独立性预后影响因素;食管钡餐造影病变长度(P=0.0037)为患者局部控制率的独立性预后影响因素。结论 食管钡餐造影病变长度为临床无转移食管癌主要预后影响因素,在临床上应对食管钡餐造影病变较长的患者给予足够的重视,并予以积极治疗。

     

    Abstract: Objective To investigate the effect of tumor local factors on the prognosis of non-metastasis esophageal squamous cell carcinoma(ESCC) patients. Methods We retrospectively analyzed the clinical data of 263 ESCC patients. The effects of barium meal length, GTV maximum diameter, GTV length and GTV volume on the prognosis of patients were analyzed. Results ROC curve analysis showed that the prognosis critical value of barium meal length, GTV maximum diameter, GTV length and GTV volume were 4.25, 1.80, 5.85 cm and 27.98 cm3, respectively. Univariate analysis showed that barium meal length(P=0.0004), GTV maximum diameter(P=0.0246), GTV length(P=0.0035) and GTV volume (P=0.0184) were the prognostic factors for survival rate; the barium meal length (P=0.0149) was the prognostic factor for local control rate. Multivariate analysis showed that barium meal length(P=0.0013), GTV maximum diameter(P=0.0047) and GTV length(P=0.0032) were the independent prognostic factors for survival rate; the barium me al length(P=0.0037) was the independent prognostic factor for local control rate. Conclusion The ba-rium meal length is the main prognosis factor for non-metastasis ESCC patients, so we suggest that the clinical physician must give enough attention and active treatment to the patients with long barium meal.

     

  • [1] Su N, Wang YD, Li CL, et al. The effect of tumor length, maximum diameters and volume on the response of N0 stage thoracic esophageal squamous cell carcinoma[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2014, 23(1): 27-30. [苏娜, 王雅棣, 李成林, 等. N0期胸段食管癌GTV长度和最大直径及体积对放 疗预后影响[J]. 中华放射肿瘤学杂志, 2014, 23(1): 27-30.]
    [2] Xie YT, Wang SQ, Huang JQ, et al. Analysis of prognostic factors in patients with thoracic esophageal squamous carcinoma after radical resection[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2004, 7( 6): 453-5. [谢映涛, 王树钦, 黄金球, 等. 影响胸段食管鳞癌切 除术预后的因素[J].中华胃肠外科杂志, 2004, 7(6): 453-5.]
    [3] Zhang HL, Ping YM, Du XQ. Analysis of prognostic factors with Cox model in esophageal cancer after radical resection[J].Zhonghua Zhong Liu Za Zhi,1999,21(1):32-4. [张合林, 平育敏, 杜喜群. 应用Cox模型分析影响食管癌切除术后的预后因素[J]. 中华肿瘤杂志, 1999, 21(1): 32-4.]
    [4] Zhu SC, Li R, Li J, et al. Preliminary study on the relationship between stage and prognosis of nonoperation treatment of thoracic esophageal carcinoma[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2004, 13(1): 189-92. [祝淑钗, 李任, 李娟, 等. 非 手术治疗胸段食管癌临床分期与预后关系的初步探讨[J]. 中华 放射肿瘤学杂志, 2004, 13(1): 189-92.]
    [5] Shen WB, Zhu SC, Li J, et al. Prognostic effect of clinical staging for esophageal carcinoma patients with three-dimensional conformai radiotherapy[J]. Zhonghua Fang She Yi Xue Yu Fang Hu Za Zhi, 2008, 28(4): 371-4. [沈文斌, 祝淑钗, 李娟, 等. 食管 癌临床分期对三维适形放射治疗预后的影响[J]. 中华放射医学 与防护杂志, 2008, 28(4): 371-4.]
    [6] Griffiths EA, Brummell Z, Gorthi G, et al.Tumor length as a prognostic factor in esophageal malignancy:univariate and multivariate survival analyses[J]. J Surg Oncol, 2006, 93(4): 25 8-67.
    [7] Bolton WD, Hofstetter WL, Francis AM, et al. Impact of tumor length on long-term survival of pT1 esophageal adenocarcinoma[J]. J Thorac Cardiovasc Surg, 2009, 138(4): 83 1-6.
    [8] Wang L, Kong J, Han C, et al. Analysis the long-term effect of 78 1 patients with different parts of esophageal carcinoma treated by three-dimensional conformal radiotherapy[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2013, 22(1): 18-21. [王澜, 孔洁, 韩春, 等. 781例不同部位食管癌三维放疗预后分析[J]. 中华放射肿瘤 学杂志, 2013, 22(1): 18-21.]
    [9] Shen WB, Zhu SC, Gao HM, et al. Analysis of failure patterns of three-dimensional conformal radiotherapy alone in resectable esophageal cancer[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 20 13, 22(3): 205-8. [沈文斌, 祝淑钗, 高红梅, 等. 可手术切除食 管癌单纯三维适形放疗失败原因分析[J]. 中华放射肿瘤学杂 志, 2013, 22(3): 205-8.]
    [10] Li J, Zhu SC, Wang YX, et al. Analysis the long-term effect of 375 patients with esophageal carcinoma treated by three-dimensional conformal radiotherapy[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2012, 21(4): 334-8. [李娟, 祝淑钗, 王玉祥, 等. 375例 食管癌三维适形放疗长期疗效分析[J]. 中华放射肿瘤学杂志, 20 12, 21(4): 334-8.]
    [11] Li XN, Wang L, Han C, et al. Analysis of relationship between CT-GTV and prognosis in patients with esophageal cancer after three-dimensional radiotherapy[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2014, 24(1): 23-6. [李晓宁, 王澜, 韩春, 等. 食管癌 CT图像GTV与三维放疗预后关系分析[J]. 中华放射肿瘤学杂 志, 2014, 24(1): 23-6.]
    [12] Xu Q, Liu ZK, Cao YK, et al. Relationship of gross tumor volume with lymph node metastasis and prognosis of esophageal carcinoma[J]. Zhonghua Zhong Liu Za Zhi, 2012, 34(9): 684-7. [许茜, 刘志坤, 曹彦坤, 等. 食管癌大体肿瘤靶区体积与淋巴结 转移及预后的关系[J]. 中华肿瘤杂志, 2012, 34(9): 684-7.]
计量
  • 文章访问数:  1478
  • HTML全文浏览量:  335
  • PDF下载量:  648
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-08-20
  • 修回日期:  2014-11-25
  • 刊出日期:  2015-08-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭