Abstract: During the past ten years, circulating tumour cells(CTCs) have received enormous attention as new biomarkers for cancer. They also have been confirmed as the origin of tumor metastasis and play an important role in tumor metastasis. Since CTCs can be isolated in a non-invasive way, they help us to better understand the molecular mechanism of tumor biological characteristics and tumor cells metastasis. In the earlier stages of some cancers, CTCs also can be used as new biomarkers for cancer screening, prognosis and monitoring the efficacy of anticancer therapies. In this review, we focus on the clinical potential value of CTCs as novel biomarkers on early bladder cancer.