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局部晚期非小细胞肺癌同步放化疗并序贯化疗与单纯序贯放化疗的对比研究

余建云, 李林均, 陈萍, 张军, 许涛, 程雄飞

余建云, 李林均, 陈萍, 张军, 许涛, 程雄飞. 局部晚期非小细胞肺癌同步放化疗并序贯化疗与单纯序贯放化疗的对比研究[J]. 肿瘤防治研究, 2015, 42(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2015.06.016
引用本文: 余建云, 李林均, 陈萍, 张军, 许涛, 程雄飞. 局部晚期非小细胞肺癌同步放化疗并序贯化疗与单纯序贯放化疗的对比研究[J]. 肿瘤防治研究, 2015, 42(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2015.06.016
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YU Jianyun, LI Linjun, CHEN Ping, ZHANG Jun, XU Tao, CHENG Xiongfei. Comparison Between Concurrent Chemoradiotherapy plus Sequential Chemotherapy and Sequential Chemoradiotherapy Alone on Locally Advanced Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2015.06.016
Citation: YU Jianyun, LI Linjun, CHEN Ping, ZHANG Jun, XU Tao, CHENG Xiongfei. Comparison Between Concurrent Chemoradiotherapy plus Sequential Chemotherapy and Sequential Chemoradiotherapy Alone on Locally Advanced Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2015.06.016
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局部晚期非小细胞肺癌同步放化疗并序贯化疗与单纯序贯放化疗的对比研究

  • 442000 十堰，湖北医药学院附属人民医院肿瘤中心

详细信息
    作者简介:

    余建云（1981-），女，硕士，主治医师，主要从事肿瘤放化疗研究

    通讯作者:

    李林均，E-mail: lilinjun@163.com

  • 中图分类号: R734.2

Comparison Between Concurrent Chemoradiotherapy plus Sequential Chemotherapy and Sequential Chemoradiotherapy Alone on Locally Advanced Non-small Cell Lung Cancer Patients

  • Department of Chemo-radiation Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China

摘要

    摘要
  • 摘要: 目的 观察局部晚期非小细胞肺癌（NSCLC）接受调强放疗（IMRT）联合同步吉西他滨和卡铂方案（GC）化疗与序贯放化疗的近、远期疗效和不良反应。方法 回顾性分析不能进行手术治疗和拒绝手术治疗的局部晚期NSCLC患者65例，其中同步放化疗并序贯化疗组给予IMRT同步联合GC治疗者32例，单纯序贯放化疗组为33例给予IMRT后序贯GC治疗。通过统计分析比较两组之间的近期有效率、远期生存率和不良反应。结果 两组均完成治疗，随访率100%，同步放化疗并序贯化疗组近期有效率为75%，单纯序贯放化疗组为66.7% ，两组比较差异有统计学意义（P＜0.05）。两组1、3年生存率相比较，同步放化疗并序贯化疗组为68. 2% 、20. 5% ；单纯序贯放化疗组为 50. 1% 、11.3%；同步放化疗并序贯化疗组明显优于单纯序贯放化疗组（P＜0.05）。两组不良反应情况对比，差异无统计学意义（P＞0.05）。结论 IMRT同步联合GC方案并序贯化疗治疗局部晚期NSCLC，可以提高患者的远期生存率且不良反应可耐受。

     

    Abstract: Objective To investigate short-term and long-term efficacy and toxicity of intensitymodulated radiotherapy(IMRT) in combination with gemcitabine and carboplatin solution(GC) plus sequential chemotherapy and sequential chemoradiotherapy alone on locally advanced non-small cell lung cancer(NSCLC) patients. Methods We retrospectively analyzed 65 patients with locally advanced NSCLC who were not allowed and refused to receive operation. Thirty-two patients received IMRT with concurrent GC regimen and sequential chemotherapy, and 33 patients were treated with sequential chemoradiotherapy alone. Short-term and long-term efficacy and toxicity of two groups were compared by statistical analysis. Results All patients finished their course of treatment and the follow-up rate was 100%. The short-term response rate of IMRT combined with chemotherapy and sequential chemotherapy group was 75%, and the rate of sequential chemoradiotherapy alone group was 66.7% (P<0.05). The 1- and 3-year overall survival(OS) rates of the combination group were 68.2% and 20.5%, respectively, while those of sequential chemoradiotherapy alone group were 50.1% and 11.3%, respectively(P<0.05). No difference of toxicity between two group was observed (P>0.05). Conclusion It could increase the long-term survival rate of patients with locally advanced NSCLC by IMRT combined with GC and sequential chemotherapy and the toxicity of treatment could be tolerated.

     

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    • 参考文献(14)
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出版历程
  • 收稿日期:  2014-06-16
  • 修回日期:  2015-02-09
  • 刊出日期:  2015-06-24

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