Abstract: Objective To investigate the accuracy of mammography(MG), color Doppler ultrasonography(CDUS) and magnetic resonance imaging(MRI) in predicting ductal carcinoma in situ(DCIS). Methods We collected 26 DCIS patients treated in the Clinical Medical College of Guiyang Medical University from July 2009 to September 2014, and examined them using MG, CDUS and MRI methods respectively. The diagnose accuracy of those imaging methods were compared by Kruskal-Wallis test. Results There were calcification(73%, 19/26), structural disorder(36%, 8/26), and nodule(30%, 7/26) in the MG appearance of DCIS, and the dense microcalcification was remarkably performed(70%, 18/26). CDUS had performances like nodule(85%, 22/26), ductal ectasia(11.5%, 3/26), and low echo-level nodule without capsular was typical performance(59%, 13/22). Non-mass like enhancement was typical performance in enhanced MRI(73%, 19/26), most of TIC curves appeared as Ⅱand Ⅲ types(73%, 19/26). The accuracy of MG，CDUS and MRI imaging were 77%，50% and 85%, respectively. The accuracy could rise to 85% when both MG and CDUS were combined and 96% when the three methods were combined simultaneously(P＜0.05). Conclusion DCIS could be predicted by MG, CDUS, and MRI respectively, and all these three techniques have advantages and disadvantages, moreover, the combination of different imaging techniques could improve the predicting accuracy significantly.