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贝伐珠单抗治疗复发性卵巢癌的应用进展

王营, 郭志, 倪虹

王营, 郭志, 倪虹. 贝伐珠单抗治疗复发性卵巢癌的应用进展[J]. 肿瘤防治研究, 2015, 42(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2015.04.022
引用本文: 王营, 郭志, 倪虹. 贝伐珠单抗治疗复发性卵巢癌的应用进展[J]. 肿瘤防治研究, 2015, 42(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2015.04.022
WANG Ying, GUO Zhi, NI Hong. Bevacizumab in Treatment of Recurrent Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2015.04.022
Citation: WANG Ying, GUO Zhi, NI Hong. Bevacizumab in Treatment of Recurrent Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2015.04.022

贝伐珠单抗治疗复发性卵巢癌的应用进展

详细信息
    作者简介:

    王营(1988-),女,硕士在读,主要从事肿瘤的微创治疗及肿瘤耐药相关临床与基础研究

    通讯作者:

    倪虹,E-mail:wnihong@aliyun.com

  • 中图分类号: R737.31

Bevacizumab in Treatment of Recurrent Ovarian Cancer

  • 摘要: 贝伐珠单抗(Bevacizumab, BEV)是一种重组人源化抗血管内皮生长因子(vascularendothelial growth factor, VEGF)的单克隆抗体,通过阻断VEGF与其受体结合,抑制肿瘤新生血管形成,从而抑制肿瘤生长。临床研究表明,BEV单药治疗复发性卵巢癌的疗效确切,并且与紫杉类药物、脂质体阿霉素及环磷酰胺等药物联合使用疗效更佳。此外,BEV能有效控制恶性腹水,提高患者的生活质量。因此BEV在复发性卵巢癌的治疗中具有广阔的应用前景。

     

    Abstract: Bevacizumab(BEV), a recombinant humanized anti-VEGF monoclonal antibody, represses the tumor angiogenesis by blocking the binding of VEGF to its receptors,thus to inhibit the growth of malignancies. Clinical studies have demonstrated that BEV is active as a single agent for recurrent ovarian cancer, and exhibits better efficacy when combines with cytotoxic drugs, such as taxane, pegylated liposomal doxorubicin, cyclophosphamide and so on. Moreover, BEV plays an important role in the management of malignant ascites caused by ovarian cancer and significantly improves the patients' quality of life. Therefore,BEV has broad prospects in the treatment of recurrent ovarian cancer.

     

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出版历程
  • 收稿日期:  2014-05-18
  • 修回日期:  2014-07-29
  • 刊出日期:  2015-04-24

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