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干扰素治疗慢性骨髓增殖性肿瘤的临床意义

丁莉, 许娜, 黄彬涛, 高冠论, 肖雅娟, 周璇, 卢绮思, 李琳, 李玉玲, 黄继贤, 刘晓力

丁莉, 许娜, 黄彬涛, 高冠论, 肖雅娟, 周璇, 卢绮思, 李琳, 李玉玲, 黄继贤, 刘晓力. 干扰素治疗慢性骨髓增殖性肿瘤的临床意义[J]. 肿瘤防治研究, 2015, 42(04): 385-388. DOI: 10.3971/j.issn.1000-8578.2015.04.015
引用本文: 丁莉, 许娜, 黄彬涛, 高冠论, 肖雅娟, 周璇, 卢绮思, 李琳, 李玉玲, 黄继贤, 刘晓力. 干扰素治疗慢性骨髓增殖性肿瘤的临床意义[J]. 肿瘤防治研究, 2015, 42(04): 385-388. DOI: 10.3971/j.issn.1000-8578.2015.04.015
DING Li, XU Na, HUANG Bintao, GAO Guanlun, XIAO Yajuan, ZHOU Xuan, LU Qisi, LI Lin, LI Yuling, HUANG Jixian, LIU Xiaoli. Therapeutic Effect of Interferon on Chronic Myeloproliferative Neoplasm Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 385-388. DOI: 10.3971/j.issn.1000-8578.2015.04.015
Citation: DING Li, XU Na, HUANG Bintao, GAO Guanlun, XIAO Yajuan, ZHOU Xuan, LU Qisi, LI Lin, LI Yuling, HUANG Jixian, LIU Xiaoli. Therapeutic Effect of Interferon on Chronic Myeloproliferative Neoplasm Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 385-388. DOI: 10.3971/j.issn.1000-8578.2015.04.015

干扰素治疗慢性骨髓增殖性肿瘤的临床意义

基金项目: 广州市科技攻关计划-科技攻关引导项目(2006Z3-E0401)
详细信息
    作者简介:

    丁莉(1988-),女,硕士,主要从事血液病相关肿瘤的基础研究与临床工作

    通讯作者:

    刘晓力,E-mail:lxl2405@126.com

  • 中图分类号: R733.3

Therapeutic Effect of Interferon on Chronic Myeloproliferative Neoplasm Patients

  • 摘要: 目的 评价干扰素-α(IFN-α)对慢性骨髓增殖性肿瘤(MPN)患者的临床疗效。方法 回顾性分析110例进展期MPN病例,其中包括76例JAK2V617F突变阳性或阴性原发性血小板增多症(ET)患者,34例JAK2V617F突变阳性真性红细胞增多症(PV)患者,分别接受IFN-α及羟基脲(HU)治疗半年以上,分析其临床数据,评价疗效和不良反应,并进行随访。结果 JAK2V617F(+)的ET及PV患者,IFN及HU治疗组间总缓解率差异无统计学意义(89.5% vs. 85.7%;87.5% vs. 83.3%,P>0.05),IFN治疗组5年无疾病进展生存率显著高于HU治疗组(84.2% vs. 52.4%;87.5% vs. 50.0%,P<0.05)。JAK2V617F(-)的ET患者,IFN和HU治疗组间总缓解率(82.4% vs.78.9%)及5年无疾病进展生存率(58.8% vs. 57.9%)间差异均无统计学意义(P>0.05) 。IFN治疗组患者治疗过程中血栓事件、脾肿大、骨髓纤维化发生率均较HU治疗组低,且HU治疗组血液学(1~2级)不良反应较IFN组更多见,差异有统计学意义(P<0.05)。结论 JAK2V617F突变阳性的ET和PV患者使用干扰素治疗可获得较好的无疾病进展生存,且对JAK2V617F阳性PV患者摆脱静脉放血治疗效果理想。

     

    Abstract: Objective To evaluate the therapeutic effect of interferon alpha(IFN-α) on patients with chronic myeloproliferative neoplasm(MPN). Methods We retrospectively made an analysis of 110 advanced MPN patients diagnosed, including 76 essential thrombocytosis(ET) patients with or without JAK2V617F mutation and 34 polycythemia vera(PV) patients with JAK2V617F mutation. All patients received IFN-α or hydroxyurea(HU) therapy for more than 6 months. The clinical data of efficacy and side effects were observed and compared. Results The overall response rate(ORR) between IFN-α and HU treatment groups of ET and PV patients with JAK2V617F mutations had no significant difference(89.5% vs. 85.7%;87.5% vs. 83.3%, P>0.05), but the 5-year progression-free survival(PFS) rate of IFN-α and HU treatment groups showed significant difference(84.2% vs. 52.4%;87.5% vs. 50.0%, P<0.05). ORR(82.4% vs. 78.9%) and 5-year PFS rate(58.8% vs. 57.9%) between IFN-α and HU treatment groups of ET patients without JAK2V617F mutations had no significant difference(P>0.05). The thromboembolic events, splenomegaly, bone marrow fibrosis of IFN-α treatment group were lower than those of HU treatment group; while hematologic adverse reactions of HU treatment group(Grade 1-2) was more than that of IFN-α treatment group (P<0.05). Conclusion ET and PV patients with JAK2V617F mutations who were treated with IFN-α could get a favorable progressionfree survival, and PV patients with JAK2V617F mutations could get rid of phlebotomy.

     

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出版历程
  • 收稿日期:  2014-07-01
  • 修回日期:  2014-08-25
  • 刊出日期:  2015-04-24

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