血清25-羟基维生素D3及钙水平与胃癌的关系

曾亚菲; 褚燕君; 孙静

doi:10.3971/j.issn.1000-8578.2015.04.011

血清25-羟基维生素D3及钙水平与胃癌的关系

450001 郑州，郑州大学第一附属医院消化科

详细信息

作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

中图分类号: R735.2
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出版历程
- 收稿日期: 2014-05-11
- 修回日期: 2014-08-01
- 刊出日期: 2015-04-24

Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450001, China

摘要

摘要: 目的探讨血清25-(OH)D3及钙（Ca²⁺）水平与胃癌的关系。方法选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎（对照组）患者63例，胃癌（病例组）患者118例。采用酶联免疫吸附法（ELISA）测定入选对象血清25-(OH)D3水平，离子选择性电极（ISE）电位法测定入选对象血清Ca²⁺水平。结果病例组外周血25-(OH)D3水平显著低于对照组（t=15.07，P=0.000），而其血清Ca水平与对照组比较，差异无统计学意义（t=1.109，P=0.269），病例组内血清25-(OH)D3水平与Ca²⁺之间呈正相关（r=0.706，P=0.000）。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义（F=3.356，P=0.038）。胃癌经手术治疗后，术后外周血25-(OH) D3水平高于术前，差异有统计学意义（t=−8.017，P=0.000）。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义（t=0.061，P=0.952）。结论血清 25-(OH)D3水平可能与胃癌的发生、发展相关，手术治疗后其水平明显升高，可用于监测胃癌患者病情变化、预测预后。
- 胃癌 /
- 25-羟基维生素D3 /
- Ca /
- 酶联免疫吸附法
Abstract: Objective To investigate the association between serum 25-(OH) D3, Ca²⁺ and gastric cancer. Methods A total of 63 patients pathologically diagnosed as chronic superficial gastritis(Control group) and a total of 118 patients pathologically diagnosed as gastric cancer(Case group) were selected from The First Affiliated Hospital of Zhengzhou University. The level of serum 25-(OH) D3 was measured by ELISA, and the level of Ca²⁺ was measured by ISE potential method. Results The level of 25-(OH) D3 of case group was significantly lower than that of control group(t=15.07, P=0.000), but no significance was found in comparison of Ca²⁺ between them(t=1.109, P=0.269). There was a positive correlation between serum 25-(OH) D3 concentration and Ca²⁺ in case group(r=0.706, P=0.000). The difference of 25-(OH) D3 levels among case groups with different cell differentiation degrees was statistically significant(F=3.356, P=0.038). When patients had taken gastric operation, the serum level of 25-(OH) D3 was higher in postoperative group than that in preoperative group（t=−8.017, P=0.000）. However, no statistical significance was found between positive lymph node metastasis group and negative lymph node metastasis group (t=0.061, P=0.952). Conclusion The level of serum 25-(OH) D3 may be associated with the occurrence and development of gastric cancer, and it is significantly increased after surgery; therefore, the serum 25-(OH) D3 could be used to monitor gastric carcinoma patients' conditions, prediction and prognosis.
- Gastric carcinoma /
- 25-(OH) D3 /
- Ca²⁺ /
- ELISA

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参考文献(14)

[1]	Wang JM, Lin SR. Research and new treatment progress of gastric cancer[J].Wei Chang Bing Xue He Gan Bing Xue Za Zhi, 2012, 21 (1): 3-5. [王婕敏, 林三仁. 胃癌研究及诊治新进展[J]. 胃肠病学和肝病学杂志, 2012, 21(1): 3-5.]
[2]	Fu XJ, Chen RC. Clinical significance of seasonal changes of 25 -(OH) D in inflammatory bowel disease patients [J]. Fang She Mian Yi Xue Za Zhi, 2013, 26(3): 362-4.[傅晓娟, 陈如昌. 炎症性肠病患者25-羟基维生素D季节变化的临床意义[J]. 放射免疫学杂志, 2013, 26(3): 362-4.]
[3]	Yamana K, Saito H, Takenouchi K, et al. Vitamin D and cancer[J]. Clini Calcium, 2006, 16(7): 1147-53.
[4]	Xue M, Fang Y, Sun G, et al. IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer [J] PLoS One, 2013, 8(12): e81423.
[5]	Miao YE, Wang J, Wang WB. Expression of vitamin D receptor in gastric carcinoma and normal mucosa adjacent to carcinoma[J]. Shandong Da Xue Xue Bao(Yi Xue Ban), 2012, 50(2): 74-7. [缪玉娥, 王珏, 王潍博. 胃癌及其癌旁黏膜中维生素D受体的表达 [J] 山东大学学报（医学版）, 2012, 50(2): 74-7.]
[6]	Shi X, Li X, Chen L, et al. Analysis of somatostatin receptors and somatostatin promoter methylation in human gastric cancer[J]. Oncol Lett, 2013, 6(6): 1794-8.
[7]	Zhuang ZG, Yu JM, Jiang BQ, et al. Measurement and clinical significance of serum 25-(OH)D in breast cancer patients[J]. Shi Yong Yi Xue Za Zhi, 2010, 26(2):244-6. [庄志刚, 余剑敏, 蒋蓓琦, 等. 乳腺癌患者外周血25羟基维生素D测定及临床意义[J]. 实用医学杂志, 2010, 26(2): 244-6.]
[8]	Finkelmeier F, Kronenberger B, Köberle V, et al. Severe 25 -hydroxyvitamin D deficiency identifies a poor prognosis in patients hepatocellular carcinoma a prospective cohort study[J]. Aliment Pharmacol Ther, 2014, 39(10): 1204-12.
[9]	Kilkkinen A, Knekt P, Heliövaara M, et al. Vitamin D status and the risk of lung Cancer: a cohort study in Finland[J]. Cancer Epidemiol Biomarkers Prev, 2008, 17(11): 3274-8.
[10]	Hong SN, Kim JH, Choe WH, et al. Circulating vitamin D and colorectal adenoma in asymptomatic average-risk individuals who underwent first screening colonoscopy: a case-control study[J]. Dig Dis Sci, 2012, 57(3): 753-63.
[11]	Wulaninqsih W, Michaelsson K, Garmo H, et al. Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study[J]. BMC Public Heath, 2013, 13(1): 663.
[12]	Galas A, Augustyniak M, Sochacka-Tatara E. Does dietary calcium interact fiber against colorectal cancer? A case-control study in Central Europe[J]. Nutr J, 2013, 12: 134.
[13]	Kim KZ，Shin A, Kim J, et al. Association between CASR polymorphisms, calcium intake, and colorectal cancer risk[J]. PLoS One, 2013, 8(3): e59628.
[14]	Xie BJ, Zheng CM, Peng JR. Clinical significance of peripheral 25 -(OH)D measuring in gastrointestinal cancer patients[J]. Hebei Yi Yao, 2011, 33(24): 3711-2. [谢宝江, 郑晟旻, 彭吉润. 消化道恶性肿瘤患者外周血25-羟基维生素D测定的临床意义[J]. 河北医药, 2011, 33(24): 3711-2.]

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血清25-羟基维生素D3及钙水平与胃癌的关系

作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

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Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma

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血清25-羟基维生素D3及钙水平与胃癌的关系

作者简介: 曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者: 褚燕君，E-mail: 595056695@qq.com

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Relationship Between Serum 25-(OH) D3, Ca2+ and Gastric Carcinoma

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作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma