血清25-羟基维生素D3及钙水平与胃癌的关系

曾亚菲; 褚燕君; 孙静

doi:10.3971/j.issn.1000-8578.2015.04.011

血清25-羟基维生素D3及钙水平与胃癌的关系

450001 郑州，郑州大学第一附属医院消化科

详细信息

作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

中图分类号: R735.2
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- 文章访问数: 1525
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出版历程
- 收稿日期: 2014-05-11
- 修回日期: 2014-08-01
- 刊出日期: 2015-04-24

Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450001, China

摘要

摘要: 目的探讨血清25-(OH)D3及钙（Ca²⁺）水平与胃癌的关系。方法选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎（对照组）患者63例，胃癌（病例组）患者118例。采用酶联免疫吸附法（ELISA）测定入选对象血清25-(OH)D3水平，离子选择性电极（ISE）电位法测定入选对象血清Ca²⁺水平。结果病例组外周血25-(OH)D3水平显著低于对照组（t=15.07，P=0.000），而其血清Ca水平与对照组比较，差异无统计学意义（t=1.109，P=0.269），病例组内血清25-(OH)D3水平与Ca²⁺之间呈正相关（r=0.706，P=0.000）。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义（F=3.356，P=0.038）。胃癌经手术治疗后，术后外周血25-(OH) D3水平高于术前，差异有统计学意义（t=−8.017，P=0.000）。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义（t=0.061，P=0.952）。结论血清 25-(OH)D3水平可能与胃癌的发生、发展相关，手术治疗后其水平明显升高，可用于监测胃癌患者病情变化、预测预后。
- 胃癌 /
- 25-羟基维生素D3 /
- Ca /
- 酶联免疫吸附法
Abstract: Objective To investigate the association between serum 25-(OH) D3, Ca²⁺ and gastric cancer. Methods A total of 63 patients pathologically diagnosed as chronic superficial gastritis(Control group) and a total of 118 patients pathologically diagnosed as gastric cancer(Case group) were selected from The First Affiliated Hospital of Zhengzhou University. The level of serum 25-(OH) D3 was measured by ELISA, and the level of Ca²⁺ was measured by ISE potential method. Results The level of 25-(OH) D3 of case group was significantly lower than that of control group(t=15.07, P=0.000), but no significance was found in comparison of Ca²⁺ between them(t=1.109, P=0.269). There was a positive correlation between serum 25-(OH) D3 concentration and Ca²⁺ in case group(r=0.706, P=0.000). The difference of 25-(OH) D3 levels among case groups with different cell differentiation degrees was statistically significant(F=3.356, P=0.038). When patients had taken gastric operation, the serum level of 25-(OH) D3 was higher in postoperative group than that in preoperative group（t=−8.017, P=0.000）. However, no statistical significance was found between positive lymph node metastasis group and negative lymph node metastasis group (t=0.061, P=0.952). Conclusion The level of serum 25-(OH) D3 may be associated with the occurrence and development of gastric cancer, and it is significantly increased after surgery; therefore, the serum 25-(OH) D3 could be used to monitor gastric carcinoma patients' conditions, prediction and prognosis.
- Gastric carcinoma /
- 25-(OH) D3 /
- Ca²⁺ /
- ELISA

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参考文献(14)

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血清25-羟基维生素D3及钙水平与胃癌的关系

作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

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Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma

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血清25-羟基维生素D3及钙水平与胃癌的关系

作者简介: 曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者: 褚燕君，E-mail: 595056695@qq.com

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Relationship Between Serum 25-(OH) D3, Ca2+ and Gastric Carcinoma

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作者简介:
曾亚菲（1989-），女，硕士，主要从事消化道肿瘤的研究

通讯作者:
褚燕君，E-mail: 595056695@qq.com

Relationship Between Serum 25-(OH) D3, Ca²⁺ and Gastric Carcinoma