Abstract: Objective To investigate the trend of mortality of female breast cancer patients from 1988 to 2012, and to predict the mortality of breast cancer patients from 2013 to 2020 in He'nan Province. Methods The records of female breast cancer patients death and the population data from 1988 to 2012 in He'nan Province were drawn from He'nan Provincial Center for Tumor and Health Statistics Database.The period-specific mortality rates and the age-adjusted mortality rates directly standardized to Chinese population and the world populations were calculated. The time trend of mortality was estimated by Joinpoint model. The mortality of breast cancer patients from 2013 to 2020 in He'nan Province was predicted using Bayesian age-periodcohort model. Results The age-standardized mortality of female breast cancer patients in He'nan Province was rising from 2.68/100,000 during 1988-1992 to 5.04/100,000 during 2008-2012. The age-specific mortality over 30 was increased greatly with age. The trend parameters estimated by Joinpoint model demonstrated that the breast cancer mortality in urban area was increased before 2000 and dropped slightly in recent years, but the rate was increased constantly in rural area. Predictive model showed that the mortality rate in urban area would change little during 2013-2020, however, it would be increased from 7.84/100,000 to 9.14/100,000 in rural area. Conclusion There is an obvious upward trend of mortality of female breast cancer patents from 1988 to 2012. And the burden of breast cancer in rural area would be increased greatly from 2013 to 2020.