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食物摄入对直肠癌患病风险影响的Meta分析

Effect of Food Intake on Risk of Rectal Cancer: A Meta-analysis

  • 摘要: 通过Meta分析探讨蔬菜、水果、豆类及谷类摄入与直肠癌的关系,为降低直肠癌的患病风险提供理论依据。方法 通过Pubmed、SpringerLink、ScienceDirect、万方、中国知网、中国生物医学文献、维普等数据库检索有关蔬菜、水果、豆类及谷类与直肠癌关系的文献,并对纳入文献采用Newcastle-Ottawa量表进行质量评价,提取数据后,利用Review Manage 5.2软件对数据进行分析,合并效应量为OR值及95%CI。结果 最终纳入8篇文献,经Meta分析发现蔬菜、豆类是直肠癌的防护因素,合并OR值分别为0.81(95%CI: 0.74~0.89),0.85(95%CI: 0.77~0.94);未发现水果、谷类与直肠癌的关系,合并OR值分别为1.01(95%CI: 0.84~1.21),0.94(95%CI: 0.75~1.17)。结论 蔬菜、豆类可降低直肠癌的患病风险,适当增加摄入量可预防直肠癌的发生。

     

    Abstract: Objective To explore the relationship between vegetables, fruit, soy food or grains intake and rectal cancer, and to provide evidence for decreasing the risk of rectal cancer. Methods Literatures about the relationship between vegetables, fruit, soy food or grains and rectal cancer were searched on Pubmed, SpringerLink, ScienceDirect, Wangfang, CNKI, CBM, VIP database. Included literatures were evaluated by Newcastle-Ottawa scales. The data were extracted and analysed. The pooled odd ratio(OR) and 95% CI were calculated through Review Manage 5.2. Results Eight literatures were included finally. Total vegetables and soy food were protective factors for rectal cancer, and the pooled OR were 0.81(95%CI: 0.74-0.89) and 0.85(95%CI: 0.77-0.94) respectively. We did not find the relationship between fruit, grains and rectal cancer, and the pooled OR were 1.01(95%CI: 0.84-1.21) and 0.94( 95%CI: 0.75-1.17) respectively. Conclusion Vegetables and soy food intake could decrease the risk of rectal cancer.

     

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