高级搜索

食管鳞状细胞癌组织中KiSS-1的表达及其临床意义

严宝国, 董小川, 向正凯

严宝国, 董小川, 向正凯. 食管鳞状细胞癌组织中KiSS-1的表达及其临床意义[J]. 肿瘤防治研究, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008
引用本文: 严宝国, 董小川, 向正凯. 食管鳞状细胞癌组织中KiSS-1的表达及其临床意义[J]. 肿瘤防治研究, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008
YAN Baoguo, DONG Xiaochuan, XIANG Zhengkai. Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008
Citation: YAN Baoguo, DONG Xiaochuan, XIANG Zhengkai. Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008

食管鳞状细胞癌组织中KiSS-1的表达及其临床意义

详细信息
    作者简介:

    严宝国(1966-),男,本科,副主任医师,主要从事胸与骨软组织肿瘤的基础和临床研究

    通讯作者:

    向正凯,E-mail: tjmuxzk@163.com

  • 中图分类号: R735.1

Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance

  • 摘要: 目的 探讨食管鳞状细胞癌(ESCC)组织中肿瘤转移抑制基因(KiSS-1)的表达并分析其临床意义。方法 采用实时定量PCR方法检测65例ESCC组织和同一患者的邻近正常食管组织中KiSS-1的表达及分析其与各种临床病理因数的关系。结果 KiSS-1在肿瘤组织中的表达明显低于正常食管组织(P=0.017)。同时,KiSS-1的表达缺失与肿瘤的大小、分化程度与浸润程度之间无明显的相关性(P=0.480,P=0.827,P=0.823),而与肿瘤淋巴结的转移相关。另外, KiSS-1表达缺失的患者五年生存率相对更差(P=0.009)。结论 KiSS-1表达缺失可作为ESCC发生淋巴结转移的一个指标,KiSS-1也是判断ESCC患者预后的一个指标。

     

    Abstract: Objective To investigate the expression of metastasis suppressor gene KiSS-1 in esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods Expression of KiSS-1 in 65 pairs of ESCC and adjacent normal tissues were detected by real-time quantitative RT-PCR assay, and its clinical relevance with clinicopathologic parameters was evaluated. Results KiSS-1 expression in ESCC tissues was significantly lower than those in adjacent normal tissues (P=0.017). The deficient KiSS-1 expression in ESCC tissues was correlated with lymph node metastasis but not correlated with tumor size, histological type, degree of tumor invasion or invasion to adventitia (P=0.480, P=0.827, P=0.823). In addition, the ESCC patients with deficient KiSS-1 expression had significantly poorer overall survival (P=0.009). Conclusion Deficient KiSS-1 expression may be an important biomarker for detecting lymph node metastasis in ESCC, and KiSS-1 might be a potent prognostic marker for ESCC patients.

     

  • [1] Tachibana M, Kinugasa S, Dhar DK, et al. Prognostic factors in T1 and T2 squamous cell carcinoma of the thoracic esophagus[J]. Arch Surg, 1999, 134(1): 50-4.
    [2] Hosch SB, Stoecklein NH, Pichlmeier U, et al. Esophageal cancer: the mode of lymphatic tumor cell spread and its prognostic significance[J]. J Clin Oncol, 2001,19(7): 1970-5.
    [3] Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome[J]. Am J Pathol, 2003,162(2): 609-17.
    [4] Martin TA, Watkins G, Jiang WG. KiSS-1 expression in human breast cancer[J]. Clin Exp Metastasis, 2005,22(6): 503-11.
    [5] Nicolle G, Comperat E, Nicolaïew N, et al. Metastin (KiSS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder[J]. Ann Oncol, 2007,18(3): 605-7.
    [6] Ringel MD, Hardy E, Bernet VJ, et al. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells[J]. J Clin Endocrinol Metab, 2002, 87 (5): 2399.
    [7] Cheung IY, Cheung NK. Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR[J]. Clin Cancer Res, 2001,7(6): 1698-705.
    [8] Lee JH, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene[J]. J Natl Cancer Inst, 1996, 88(23): 1731-7.
    [9] Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor[J]. Nature, 2001, 411(6837): 613-7.
    [10] Shengbing Z, Feng LJ, Bin W, et al. Expression of KiSS-1 gene and its role in invasion and metastasis of human hepatocellular carcinoma[J]. Anat Rec (Hoboken), 2009,292(8): 1128-34.
    [11] Lee KH, Kim JR. Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer[J]. Oncol Res, 2009, 18(2-3): 107-16.
    [12] Kuohung W, Kaiser UB. GPR54 and KiSS-1: role in the regulation of puberty and reproduction[J]. Rev Endocr Metab Disord, 2006, 7( 4): 257-63.
    [13] Ikeguchi M, Yamaguchi K, Kaibara N. Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma[J]. Clin Cancer Res, 2004, 10(4): 1379-83.
    [14] Curtis AE, Murphy KG, Chaudhri OB, et al. Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer[J]. Oncol Rep, 2010, 23 (6): 1729-34.
    [15] Kostadima L, Pentheroudakis G, Pavlidis N. The missing kiss of life: transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer[J]. Anticancer Res, 2007, 27(4B): 24 99-504.
计量
  • 文章访问数:  1038
  • HTML全文浏览量:  241
  • PDF下载量:  337
  • 被引次数: 0
出版历程
  • 刊出日期:  2014-09-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭