Effect of Yiqi Yangyin Recipe Combined with FOLFOX4 on Immune Function in Patients with Colorectal Cancer
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摘要: 目的 观察益气养阴中药联合FOLFOX4方案化疗对大肠癌术后患者免疫功能的影响。方法 选择60例2009年1月—2012年6月期间在龙华医院普外科接受手术并住院完成完整化疗周期的结直肠癌患者，随机分为益气养阴中药联合化疗组（治疗组）和单纯化疗组（对照组），每组30例。两组均以FOLFOX4方案化疗，治疗组在化疗期间口服益气养阴中药，早晚各一次，分别观察患者术前、术后、及化疗各个周期前的各项免疫指标，比较两组免疫指标的变化及化疗的不良反应等变化。结果 治疗组化疗各周期前后各指标变化不明显，差异无统计学意义。治疗组和对照组在手术后CD4，CD4/CD8较手术前上升，CD8较手术前有明显下降，两组间比较差异无统计学意义。经过3周期的化疗后，治疗组和对照组比CD8下降、CD4/CD8上升（P<0.05），在经过6周期化疗后治疗组和对照组比CD8下降（P<0.01）、CD3、CD4、CD4/CD8上升（P<0.01），差异有统计学意义。而治疗组化疗期间的不良反应明显比对照组轻。结论 益气养阴中药能提高肠癌患者术后辅助化疗期间的免疫功能，同时能减轻化疗期间的不良反应。Abstract: Objective To observe the effect of Yiqi Yangyin recipe(YQYY, supplementing qi, nourishing yin) combined with postoperative adjuvant chemotherapy FOLFOX4 on immune function in patients with colorectal cancer. Methods Selected 60 patients with colorectal cancer from Department of General Surgery in Longhua Hospital received operation and were hospitalized to complete the full cycle of chemotherapy from January 2009 to June 2012. These 60 patients were equally randomized into two groups, treatment group, treated with YQYY combined with chemotherapy, and control group, treated with chemotherapy alone(n=30). Both groups received FOLFOX4 chemotherapy; moreover, treatment group took YQYY during chemotherapy, twice a day. The immune indicators were observed before and after operation, and before various cycles of chemotherapy. The changes of immune indicators and side effects of chemotherapy were analyzed. Results Index change in treatment group was not statistically significant before and after all cycles of chemotherapy. CD4, CD4/CD8 were increased after operation in treatment group and control group, but CD8 was significantly decreased (P>0.05).After 3 cycles of chemotherapy, CD8 was decreased, while CD4/CD8 was increased in both groups (P<0.05). CD3,CD4,CD4/CD8 were significantly increased while CD8 was significantly decreased after 6 cycles of chemotherapy in treatment group compared with control group（P<0.01）. The side effects of chemotherapy in treatment group were significantly lighter than those in control group. Conclusion YQYY could improve the immune function and reduce the side effects in colorectal cancer patients during postoperative adjuvant chemotherapy.
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Key words:
- FOLFOX4 /
- Yiqi Yangyin recipe /
- Immune function /
- Colorectal cancer
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