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非阿司匹林类非甾体抗炎药与皮肤癌发病风险:Meta分析

朱云, 程旸, 李爱民, 罗荣城

朱云, 程旸, 李爱民, 罗荣城. 非阿司匹林类非甾体抗炎药与皮肤癌发病风险:Meta分析[J]. 肿瘤防治研究, 2014, 41(08): 897-901. DOI: 10.3971/j.issn.1000-8578.2014.08.009
引用本文: 朱云, 程旸, 李爱民, 罗荣城. 非阿司匹林类非甾体抗炎药与皮肤癌发病风险:Meta分析[J]. 肿瘤防治研究, 2014, 41(08): 897-901. DOI: 10.3971/j.issn.1000-8578.2014.08.009
ZHU Yun, CHENG Yang, LI Aimin, LUO Rongcheng. Association of Non-aspirin Non-steroidal Anti-inflammatory Drugs and Risk of Skin Cancer: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 897-901. DOI: 10.3971/j.issn.1000-8578.2014.08.009
Citation: ZHU Yun, CHENG Yang, LI Aimin, LUO Rongcheng. Association of Non-aspirin Non-steroidal Anti-inflammatory Drugs and Risk of Skin Cancer: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 897-901. DOI: 10.3971/j.issn.1000-8578.2014.08.009

非阿司匹林类非甾体抗炎药与皮肤癌发病风险:Meta分析

基金项目: 广东省自然科学基金重点项目(10251051501000008)
详细信息
    作者简介:

    朱云(1987-),女,博士在读, 主要从事肿瘤治疗基础和临床综合防治研究

    通讯作者:

    李爱民, E-mail: liaimin2005@gmail.com

    罗荣城, E-mail: luorc01@163.com

  • 中图分类号: R739.5

Association of Non-aspirin Non-steroidal Anti-inflammatory Drugs and Risk of Skin Cancer: A Meta-analysis

  • 摘要: 目的 评价非阿司匹林类非甾体抗炎药与皮肤癌发病风险的关系。方法 检索PubMed (Medline),EMBASE,BIOSIS, Cochrane图书馆,中国知网数据库(CNKI)获取有关非阿司匹林类非甾体抗炎药与皮肤癌发病风险的研究。按照纳入标准进行文献筛查、质量评价和资料提取。应用Stata软件计算总体OR值及95%置信区间,并进行偏倚分析。当异质性可以接受时,选用固定效应模型对各研究原始数据进行合并。结果 纳入非阿司匹林类非甾体抗炎药与皮肤癌发病风险的相关临床研究文献10篇,共12个独立研究,累计皮肤癌患者482 264例,合并分析结果:OR值为1.00,95%CI:0.98~1.02。结论 无足够的证据证明非阿司匹林类非甾体抗炎药与皮肤癌发病风险相关。仍需大规模临床随机对照试验来证实该结果。

     

    Abstract: Objective To evaluate the association between non-aspirin non-steroidal anti-inflammatory drugs and risk of skin cancer. Methods References about non-aspirin non-steroidal anti-inflammatory drugs and risk of skin cancer were identified in PubMed(Medline), EMBASE,BIOSIS, Cochrane library and CNKI. Literature screening, quality assessment and data collection were done according to the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and publication bias were assessed by Stata 10.0. A fixed-effect model was used to combine all original data when there is no statistically significant heterogeneity. Results A total of 12 independent studies from 10 articles consisting of 482 264 skin cancer patients were included in the analysis. The pooled OR was 1.00 and 95%CI was 0.98-1.02. Conclusion No enough evidence could prove non-aspirin non-steroidal anti-inflammatory drugs are significantly related to the risk of skin cancer. Large clinical randomized controlled trials are still needed to confirm the result.

     

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出版历程
  • 刊出日期:  2014-08-24

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