Abstract: Adhesion molecule cluster of differentiation 24(CD24), also known as differentiation antigen cluster protein, is a highly glycosylated protein, originally was discovered involving in B cell development. Thereafter, more and more researches find that CD24 also has an important role in tumor formation and metastasis. It is highly expressed in hematologic malignancies and solid tumors, such as liver cancer, lung cancer, prostate cancer, breast cancer, renal tubular cancer, etc., participating in tumor cell proliferation, invasion and metastasis. We find that CD24 is also highly expressed in ovarian cancer. Further research of CD24 in ovarian cancer will help to identify the molecular mechanisms of ovarian cancer, research and develop the effective anticancer drugs, improve the survival rate of patients with ovarian cancer.