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替吉奥联合紫杉醇或奥沙利铂治疗进展期胃癌的临床观察

曲颜丽, 汤旭山, 唐 勇

曲颜丽, 汤旭山, 唐 勇. 替吉奥联合紫杉醇或奥沙利铂治疗进展期胃癌的临床观察[J]. 肿瘤防治研究, 2014, 41(07): 811-814. DOI: 10.3971/j.issn.1000-8578.2014.07.027
引用本文: 曲颜丽, 汤旭山, 唐 勇. 替吉奥联合紫杉醇或奥沙利铂治疗进展期胃癌的临床观察[J]. 肿瘤防治研究, 2014, 41(07): 811-814. DOI: 10.3971/j.issn.1000-8578.2014.07.027
QU Yanli, TANG Xushan, TANG Yong. Clinical Observation of S-1 Combined with Oxaliplatin or Paclitaxel on Advanced Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 811-814. DOI: 10.3971/j.issn.1000-8578.2014.07.027
Citation: QU Yanli, TANG Xushan, TANG Yong. Clinical Observation of S-1 Combined with Oxaliplatin or Paclitaxel on Advanced Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 811-814. DOI: 10.3971/j.issn.1000-8578.2014.07.027

替吉奥联合紫杉醇或奥沙利铂治疗进展期胃癌的临床观察

详细信息
    作者简介:

    曲颜丽( 1973-) ,女,硕士,副主任医师,主要从事消化肿瘤综合治疗及化疗

    通讯作者:

    唐勇,E-mail:13579210892@163.com

  • 中图分类号: R735.2

Clinical Observation of S-1 Combined with Oxaliplatin or Paclitaxel on Advanced Gastric Cancer

  • 摘要: 目的 观察替吉奥(S-1)联合紫杉醇或奥沙利铂一线治疗进展期胃癌的临床疗效和不良反应。方法 91例进展期胃癌患者分为替吉奥联合奥沙利铂(SOX组)和紫杉醇(PS组)方案化疗,其中SOX组44 例,PS组47例。所有患者S-1均是80 mg/m2,分2次餐后口服,d1~d14;SOX组:奥沙利铂 130 mg/m2,d1,静脉滴注;PS组:紫杉醇 80 mg/m2,d1、8,静脉滴注。均21天为1周期。结果 SOX组和PS组的有效率分别为36.4%和40.4%(P=0.691),两组的中位无疾病进展时间(5.0月 vs. 5.4 月,P=0.45)和中位生存时间(13.5月 vs. 16.4月,P=0.76)无显著差异。SOX组和PS组的不良反应主要是中性粒细胞减少、胃肠道反应、乏力;SOX组和PS组的恶心、呕吐发生率分别为79.5%和51.1%(P<0.05)。结论 替吉奥联合紫杉醇或奥沙利铂治疗进展期胃癌有效率和生存期相当,均有较好的疗效,不良反应可以耐受。

     

    Abstract: Objective To observe the efficacy and adverse reaction of S-1 combined with oxaliplatin or paclitaxel in the treatment of advanced gastric cancer. Methods Ninety-one advanced gastric carcinoma patients were divided into two groups: SOX group(44 cases, S-1 plus oxaliplatin) and PS group (47 cases, S-1 plus paclitaxel). All cases took oral S-1, 80 mg/m2/day, d1~14; Moreover, SOX group took oxaliplatin, 130 mg /m2 on d1; PS group took paclitaxel, 80mg /m2 on d1, d8. 21 days was a cycle. Results RR in group SOX and PS were 36.4% and 40.4% (P=0.691), respectively. PFS was 5.0 months in SOX group and 5.4 months in PS group (P=0.45). OS was 13.5 months in SOX group and 16.4 months in PS group (P=0.76). Main adverse effects in two groups were neutropenia, gastrointestinal reaction and fatigue. The frequency of nausea and vomiting was 79.5% in SOX group and 51.1% in PS group(P<0.05). Conclusion RR and OS of S-1 combined with SOX or PS were similar, with good curative effect and tolerable adverse reactions.

     

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出版历程
  • 刊出日期:  2014-07-24

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