[1] |
Toftg?rd R. Hedgehog signalling in cancer[J].Cell Mol Life Sci,2000,57(12): 1720-31.
|
[2] |
Gupta S,Takebe N,Lorusso P.Targeting the hedgehog pathway in cancer[J].Ther Adv Med Oncol,2010,2(4):237-50.
|
[3] |
Katano M.Hedgehog signaling pathway as a therapeutic target in breast cancer[J].Cancer Lett,2005,227(2): 99-104.
|
[4] |
Shahi MH,Rey JA,Castresana JS.The sonic hedgehog-GLI1 signaling pathway in brain tumor development[J].Expert Opin Ther Targets,2012,16(12):1227-38.
|
[5] |
Rudin CM.Beyond the scalpel: targeting hedgehog in skin cancer prevention[J]. Cancer Prev Res (Phila),2010,3(1):1-3.
|
[6] |
Bhatia B,Potts CR,Guldal C,et al.Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma[J].Acta Neuropathol,2012, 12 3(4):587-600.
|
[7] |
Naqvi SH,Naqvi SH,Bandukda MY,et al.Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy[J]. Infect Agent Cancer,2013,8(1):17.
|
[8] |
Huycke TR,Eames BF,Kimmel CB.Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone[J].Development,2012,139(13):2371-80.
|
[9] |
Ristorcelli E,Lombardo D.Targeting Notch signaling in pancreatic cancer[J].Expert Opin Ther Targets,2010,14(5):541-52.
|
[10] |
McKee CM,Xu D,Cao Y,et al.Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma[J].J Clin Invest,2012,122(11): 40 25-36.
|
[11] |
Nakajima T,Iguchi T,Sato T.Hedgehog signaling plays roles in epithelial cell proliferation in neonatal mouse uterus and vagina[J].Cell Tissue Res,2012,348(1):239-47.
|
[12] |
Das S,Samant RS,Shevde LA.The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer[J].Int J Breast Cancer,2012,2012: 298623.
|
[13] |
Onishi H,Katano M.Hedgehog signaling pathway as a therapeutic target in various types of cancer[J]. Cancer Sci,2011,102(10): 17 56-60.
|
[14] |
Cooper MK,Wassif CA,Krakowiak PA,et al.A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis[J]. Nat Genet,2003,33(4):508-13.
|
[15] |
Makinodan E,Marneros AG.Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin[J].Exp Dermatol,2012,21(11):847-52.
|
[16] |
Flora A,Klisch TJ,Schuster G,et al.Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma[J]. Science, 2009, 326(5958): 1424-7.
|
[17] |
Kubo M,Nakamura M,Tasaki A,et al.Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer[J]. Cancer Res,2004,64(17): 6071-4.
|
[18] |
ten Haaf A,Bektas N,von Serenyi S,et al.Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival[J].BMC Cancer,2009,9:298.
|
[19] |
O’Toole SA,Machalek DA,Shearer RF,et al.Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer[J].Cancer Res,2011,71(11): 4002-14.
|
[20] |
Zhang D,Cao L,Li Y,et al.Expression of glioma-associated oncogene 2 (Gli 2) is correlated with poor prognosis in patients with hepatocellular carcinoma undergoing hepatectomy[J].World J Surg Oncol,2013,11: 25.
|
[21] |
Ding YL,Wang QS,Zhao WM,et al.Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis[J].Asian Pac J Cancer Prev,2012,13(8): 4001-5.
|
[22] |
Lee SJ,Cho SH,Yoon JY,et al.Phase II study of S-1 monotherapy in paclitaxel- and cisplatin-refractory gastric cancer[J].Cancer Chemother Pharmacol,2009,65(1):159-66.
|
[23] |
Lewis MT.Hedgehog signaling in mouse mammary gland development and neoplasia[J].J Mammary Gland Biol Neoplasia, 20 01,6(1):53-66.
|
[24] |
Xuan Y,Lin Z.Expression of Indian Hedgehog signaling molecules in breast cancer[J].J Cancer Res Clin Oncol,2009,135(2): 235-40.
|
[25] |
Goldhirsch A,Wood WC,Coates AS,et al.Strategies for subtypes- -dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011[J].Ann Oncol,2011,22(8):1736-47.
|
[26] |
Nagaria TS,Williams JL,Leduc C,et al.Flavopiridol synergizes with sorafenib to induce cytotoxicity and potentiate antitumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems[J]. Neoplasia,2013,15(8):939-51.
|
[27] |
Green JL,La J,Yum KW,et al.Paracrine Wnt signaling both promotes and inhibits human breast tumor growth[J].Proc Natl Acad Sci U S A,2013,110(17):6991-6.
|