Microwave Ablation Combined with Stereotactic Radiotherapy for Primary and Recurrent Hepatocellular Carcinoma after Interventional Treatment
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摘要: 目的 探讨微波消融联合立体定向放疗治疗介入后原发和复发性肝癌的疗效，为临床上原发和复发性肝癌治疗方法的优选提供依据。方法 回顾性分析武汉市第五医院近年来收治的106 例介入后的原发性大肝癌患者的临床资料。106例患者分为对照组（control group, CG）和观察组（observation group，OG），OG组所有病例先行立体定向放疗(适形调强放疗) ，放疗后采用微波消融治疗。CG组仅行立体定向放疗(适形调强放疗) 。比较两组患者的近期疗效、生存率及临床特征的差别。结果 对照组53例患者总缓解率为62.26%??观察组总缓解率为79.25%,高于CG组,差异有统计学意义（P < 0.05??；OG组患者的1年生存率高于CG组，差异有统计学意义（P < 0.05）。两组患者治疗前后生活质量改善情况及血清AFP差值比较差异无统计学意义（P > 0.05）；两组患者治疗期间及治疗后的恶心呕吐、发热、白细胞下降发生率、放射性肝炎及消化道溃疡的发生率比较差异无统计学意义, ??P > 0.05??。结论 微波消融联合立体定向放疗治疗介入后的原发和复发性肝癌疗效可靠，不良反应较轻，值得临床进一步研究推广。Abstract: Abstract：Objective To assess microwave ablation combined with stereotactic radiotherapy for primary and recurrent hepatocellular carcinoma after interventional treatment. Methods The clinical data of 106 primary and recurrent liver cancer patients in the fifth Hospital of Wuhan City in recent years were retrospectively analyzed．All patients were equally divided into control group (CG) and observation group(OG). OG group received stereotactic radiotherapy which was conformal intensity modulated radiotherapy, and then microwave ablation. CG group only received stereotactic radiotherapy. Short-term effects,survival rates and clinical features were compared between two groups. Results Total response rates of CG and OG were 62.26% and 79.25%(P <0.05)．1-year survival rate of OG group was higher than that in CG group(P <0.05).Quality of life in two groups before and after treatment and serum AFP had no statistical significance(P>0.05). Incidences of nausea,vomiting, fever,leucocyte decline,radioactive hepatitis and peptic ulcer in two groups during and after treatment had no statistical signifi cance(P >0.05). Conclusion Curative effect of microwave ablation combined with stereotactic radiotherapy regimen for primary and recurrent hepatocellular carcinoma is reliable，with mild adverse reactions, and worthy of further clinical research．
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Key words:
- Radiotherapy /
- Primary hepatic carcinoma /
- Microwave ablation /
- Clinical effi cacy
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