Abstract: Abstract：Objective To assess microwave ablation combined with stereotactic radiotherapy for primary and recurrent hepatocellular carcinoma after interventional treatment. Methods The clinical data of 106 primary and recurrent liver cancer patients in the fifth Hospital of Wuhan City in recent years were retrospectively analyzed．All patients were equally divided into control group (CG) and observation group(OG). OG group received stereotactic radiotherapy which was conformal intensity modulated radiotherapy, and then microwave ablation. CG group only received stereotactic radiotherapy. Short-term effects,survival rates and clinical features were compared between two groups. Results Total response rates of CG and OG were 62.26% and 79.25%(P <0.05)．1-year survival rate of OG group was higher than that in CG group(P <0.05).Quality of life in two groups before and after treatment and serum AFP had no statistical significance(P>0.05). Incidences of nausea,vomiting, fever,leucocyte decline,radioactive hepatitis and peptic ulcer in two groups during and after treatment had no statistical signifi cance(P >0.05). Conclusion Curative effect of microwave ablation combined with stereotactic radiotherapy regimen for primary and recurrent hepatocellular carcinoma is reliable，with mild adverse reactions, and worthy of further clinical research．