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胆管癌中MDM2和PTEN的表达及其相关性

侯 鑫, 秦叔逵, 欧玉荣, 李玉梅, 汪 蕊, 钱秀娟, 侯悦悦, 吴 穷

侯 鑫, 秦叔逵, 欧玉荣, 李玉梅, 汪 蕊, 钱秀娟, 侯悦悦, 吴 穷. 胆管癌中MDM2和PTEN的表达及其相关性[J]. 肿瘤防治研究, 2014, 41(06): 610-613. DOI: 10.3971/j.issn.1000-8578.2014.06.022
引用本文: 侯 鑫, 秦叔逵, 欧玉荣, 李玉梅, 汪 蕊, 钱秀娟, 侯悦悦, 吴 穷. 胆管癌中MDM2和PTEN的表达及其相关性[J]. 肿瘤防治研究, 2014, 41(06): 610-613. DOI: 10.3971/j.issn.1000-8578.2014.06.022
HOU Xin, QIN Shukui, OU Yurong, LI Yumei, WANG Rui, QIAN Xiujuan, HOU Yueyue, WU Qiong. Expressions and Relevance of MDM2 and PTEN in Bile Duct Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 610-613. DOI: 10.3971/j.issn.1000-8578.2014.06.022
Citation: HOU Xin, QIN Shukui, OU Yurong, LI Yumei, WANG Rui, QIAN Xiujuan, HOU Yueyue, WU Qiong. Expressions and Relevance of MDM2 and PTEN in Bile Duct Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 610-613. DOI: 10.3971/j.issn.1000-8578.2014.06.022

胆管癌中MDM2和PTEN的表达及其相关性

基金项目: 安徽省自然科学基金资助项目(1208085MH170);安徽省教育厅基金资助课题(KJ2013B147);蚌埠医学院研究生科研创新计划资助项目(Byycxz1313)
详细信息
    作者简介:

    侯鑫(1989-),男,硕士在读,主要从事消化系统肿瘤的诊断与治疗的研究

    通讯作者:

    吴穷,E-mail: qiongwu68@outlook.com

  • 中图分类号: R735.8

Expressions and Relevance of MDM2 and PTEN in Bile Duct Carcinoma

  • 摘要: 目的 探讨MDM2和PTEN在胆管癌(bile duct carcinoma, BDC)的表达情况,并探讨二者之间的关系及临床意义。方法 采用免疫组织化学Elivision方法检测42例胆管癌、22例癌旁组织中MDM2、PTEN的表达。结果 MDM2在BDC组织中阳性率为38.1%??显著高于癌旁组织(P <0.05)。在分化程度差、淋巴结转移的患者中,MDM2表达显著增高(P<0.05)。PTEN在BDC 组织中表达率为31.0%,显著低于癌旁组织的72.73%(χ2=10.168,P<0.05)。在肿瘤大小、分化程度、TNM分期和淋巴结转移等临床病理指标上,PTEN表达差异无统计学意义(P>0.05)。MDM2与PTEN蛋白表达在BDC组织中呈显著负相关(rs=﹣0.313,P<0.05)。结论 MDM2与胆管癌进展相关,有可能作为评价胆管癌预后的指标。

     

    Abstract: Abstract:Objective To investigate the expressions of MDM2 and PTEN in bile duct carcinoma(BDC), and to evaluate their possible relationship and clinical signifi cance. Methods The protein levels of MDM2 and PTEN were examined by Elivision immunohistochemistry in 42 samples of BDC tissues and 22 samples of adjacent hepatic tissues. Results The expression rate of MDM2 in BDC tissues was 38.1%, signifi cantly higher than that in adjacent hepatic tissues (P<0.05). Patients with low differentiation or lymph node metastasis had a higher tendency to express MDM2 in BDC tissues (P<0.05). The expression rate of PTEN was 31.0% in BDC tissues, signifi cantly lower than that in adjacent hepatic tissues (χ2=10.168, P<0.05). For the PTEN expressions in BDC tissues, no statistical signifi cance was found in clinicopathological parameters, such as tumor size, differentiation, TNM stage or lymphnode metastasis (P>0.05). The expression of MDM2 was negatively correlated with that of PTEN in BDC tissues (rs=-0.313,P<0.05). Conclusion The expression of MDM2 may be associated with the progression of BDC. It may serve as an index for prognosis of BDC.

     

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出版历程
  • 收稿日期:  2013-09-17
  • 修回日期:  2013-11-05
  • 刊出日期:  2014-06-24

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