NTR1 Expression and Its Signifi cance in Prognosis of Breast Cancer
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摘要: 目的 探讨神经降压素受体1（NTR1）在乳腺导管内癌（DCIS）及浸润性导管癌(IDC)中的表达以及NTR1在IDC中的表达与临床病理学特征和预后的关系。方法 收集天津医科大学附属肿瘤医院2003年1月至2004年12月病理诊断为DCIS的样本60例，并随机抽样128例诊断为IDC的样本,采用免疫组织化学SP法检测样本中NTR1的表达及定位。结果 NTR1阳性着色部位为细胞质，在IDC和DCIS中的阳性表达率分别为71.1% (91/128)和53.3% (32/60)，差异有统计学意义（P＜0.05）。IDC中NTR1的表达与组织学分级、肿物最大径、淋巴结状态相关(P＜0.05），且NTR1阳性表达患者比阴性表达患者复发率高（P＜0.05）。Kaplan-Meier单因素生存分析显示IDC中NTR1阳性表达对生存期的影响具有统计学意义。COX多因素分析显示NTR1阳性表达是影响预后的独立危险因素。结论 NTR1在IDC中表达明显高于DCIS，提示在乳腺癌的发生和发展中可能发挥重要的作用；NTR1阳性表达与临床病理特征密切相关且患者预后差，因此可作为乳腺癌临床诊断和判断预后的一项重要指标。Abstract: Objective To evaluate the expression of neurotensin receptor1 (NTR1) in ductal carcinoma in situ(DCIS) and invasive ductal carcinoma (IDC), and their relationships with clinicopathological parameters and prognosis of breast cancer. Methods Immunohistochemical SP method was applied to detect the expression and location of NTR1 in the breast tissues from 128 IDC patients and 60 DCIS patients, and the relationship with clinicopathologic parameters was analyzed. Results NTR1 expression was observed in the cytoplasm of cancer cells. The expression of NTR1 in IDC and DCIS were 71.1%(91/128) and 53.3%(32/60)(P＜0.05). NTR1 expression was associated with histological grade, maximum tumor diameter and lymph node status in IDC(P＜0.05), but not with age, tumor size, family history, TNM stage or menopausal status(P＞0.05). Patients with NTR1 positive expression had higher recurrence rate than negative ones. Kaplan-Meier univariate analysis revealed NTR1 positive expression had signifi cance for survival time. Cox model analysis revealed NTR1 positive expression was a dangerous factor for independent prognosis of IDC. Conclusion NTR1 may have a promoting effect on the occurrence and development of breast cancer, and could be an important index for clinical diagnosis and prognosis of breast cancer.
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Key words:
- Breast carcinoma /
- Neurotensin receptor1(NTR1) /
- Immunohistochemistry /
- Prognosis
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