Abstract: Objective To analyze the risk factors for brain metastasis from advanced breast cancer and provide clinical guide to screen high risk patients for brain metastasis. Methods T test and Chi-square Test were used for univariate analysis to find out the risk factors for brain metastasis, and these factors were analyzed by multivariable logistic regression analysis. Results Univariate analysis showed that 9 risk factors, such as tumor diameter, number of involved positive lymph nodes, molecular typing, HER2, adjuvant chemotherapy, disease-free survival, lung metastasis, local recurrence and lymph node metastasis, were statistically signifi cant for brain metastasis(P<0.05). Multivariable logistic regression analysis showed nonstandard adjuvant chemotherapy(P<0.001), lung metastasis(P=0.003) and HER2 positive(P=0.003) were high risk factors for brain metastasis from advanced breast cancer. The accuracy of prediction based on logistic regress equation for the brain metastases was 73.9%. Conclusion Risk factors for brain metastasis from advanced breast cancer are nonstandard adjuvant chemotherapy, lung metastasis and HER2 positive.