Abstract: Objective To compare the clinicopathologic features and the correlation with the drug-sensitive protein of the patients with triple negative breast cancer and those with non-triple negative breast cancer, and to analyze their clinical signifi cance in predicting the prognosis. Methods We retrospectively analyzed 227 breast cancer patients who were newly diagnosed by Fuzhou General Hospital of Nanjing Military Command from January 2010 to Octorber 2012 . Among which, 51 patients were with triple negative breast cancer and 176 patients were with non-triple negative breast cancer. The difference in clinicopathologic features and the expression of the drug-sensitive protein of the two groups was analyzed. Results Regarding clinical features, triple negative breast cancer patients who became morbid before menopause accounted for 60.8%, which was higher than non-triple negative breast cancer patients(35.8%) (P<0.05); as for histological grade, the patients with the histological grade higher than Grade Ⅱ accounted for 64.7%, while that of non-triple negative breast group was 40.9% (P<0.05); as for tumor size, lymph node status and clinical stage, there was no difference between two groups (P> 0.05). The low expression of TOPO Ⅱ, high expression of β-tubulin Ⅲ, low expression of ERCC1, and the low-level co-expression of BRCA1 and ERCC1 of the patients with triple negative breast cancer were all statistically different from those of the patients with non-triple negative breast cancer(P<0.05), while there was no signifi cant difference between the two groups in terms of Ki67 and BRCA1(P> 0.05). Conclusion Compared with non-triple negative breast cancer patients, triple negative breast cancer patients had high-risk characteristics such as higher premenopausal morbidity and histologic grade, etc.The low expression of TOPO Ⅱ, high expression of β-tubulin Ⅲ, low expression of ERCC1, and the low-level co-expression of BRCA1 and ERCC1 had certain correlation with their clinical prognosis and drug sensitivity, indicating that they may be of some signifi cance in the clinical prevention, treatment and prognosis.