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肿瘤坏死因子相关凋亡诱导配体治疗脑胶质瘤的研究进展

范存刚, 张庆俊

范存刚, 张庆俊. 肿瘤坏死因子相关凋亡诱导配体治疗脑胶质瘤的研究进展[J]. 肿瘤防治研究, 2014, 41(02): 168-172. DOI: 10.3971/j.issn.1000-8578.2014.02.019
引用本文: 范存刚, 张庆俊. 肿瘤坏死因子相关凋亡诱导配体治疗脑胶质瘤的研究进展[J]. 肿瘤防治研究, 2014, 41(02): 168-172. DOI: 10.3971/j.issn.1000-8578.2014.02.019
FAN Cungang, ZHANG Qingjun. Progress in TRAIL-based Therapy for Glioma[J]. Cancer Research on Prevention and Treatment, 2014, 41(02): 168-172. DOI: 10.3971/j.issn.1000-8578.2014.02.019
Citation: FAN Cungang, ZHANG Qingjun. Progress in TRAIL-based Therapy for Glioma[J]. Cancer Research on Prevention and Treatment, 2014, 41(02): 168-172. DOI: 10.3971/j.issn.1000-8578.2014.02.019

肿瘤坏死因子相关凋亡诱导配体治疗脑胶质瘤的研究进展

基金项目: 国家自然科学基金资助项目(81001009)
详细信息
    作者简介:

    范存刚(1978-),男,博士,主治医师,主要从事中枢神经系统肿瘤和血管病的诊断与治疗

    通讯作者:

    张庆俊,E-mail:zhangqjpku@126.com

  • 中图分类号: R730.264;R739.41

Progress in TRAIL-based Therapy for Glioma

  • 摘要: 肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-related apoptosis-inducing ligand, TRAIL)能够特异性杀伤肿瘤细胞而不损伤正常组织,是脑胶质瘤基因治疗的理想策略。新近发现以纳米粒子和干细胞作为载体能提高TRAIL的呈递效率,与蛋白酶抑制剂、化疗药物、甘珀酸钠、miRNA和PI3-激酶/mTOR抑制剂等联合使用有助于克服胶质瘤对TRAIL的耐药性,增强TRAIL的抗肿瘤功效。由此可见,TRAIL在脑胶质瘤的治疗中具有较广泛的应用前景。

     

    Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which can specifically kill tumor cells without damaging normal tissue, has been identifi ed as an ideal gene therapy strategy for glioma. Recent studies revealed that both nanoparticles and stem cells could serve as carriers to improve the delivery effi ciency of TRAIL. In addition, the combination of protease inhibitors, chemotherapy drugs, carbenoxolone sodium, miRNA, PI3-kinase/mTOR inhibitor, and etc, could overcome the glioma resistance to TRAIL and enhance the anti-tumor effect of TRAIL. To sum up, TRAIL shows promising prospects in the treatment of glioma.

     

  • [1] Capper D, Gaiser T, Hartmann C, et al. Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation[J]. Acta Neuropathol,2009,11 7( 4):445-56.
    [2] Frank S, Köhler U, Schackert G, et al. Expression of TRAIL and its receptors in human brain tumors[J]. Biochem Biophys Res Commun,1999,257(2):454-9.
    [3] Thorburn A. Tumor necrosis factor-related apoptosisinducing ligand (TRAIL) pathway signaling[J]. J Thorac Oncol,2007,2(6):461-5.
    [4] Abdulghani J, El-Deiry WS. TRAIL receptor signaling and therapeutics[J]. Expert Opin Ther Targets,2010,14(10):1091-108.
    [5] Pollack IF, Erff M, Ashkenazi A. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells[J]. Clin Cancer Res,2001,7(5):1362-9.
    [6] Perlstein B, Finniss SA, Miller C, et al. TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo[J]. Neuro Oncol,2013,15(1):29-40.
    [7] Ehtesham M, Kabos P, Gutierrez MA, et al. Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand[J]. Cancer Res,2002, 62(24):7170-4.
    [8] Shah K, Bureau E, Kim DE, et al. Glioma therapy and realtime imaging of neural precursor cell migration and tumor regression[J]. Ann Neurol,2005,57(1):34-41.
    [9] Germano IM, Uzzaman M, Benveniste RJ, et al. Apoptosis in human glioblastoma cells produced using embryonic stem cellderived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand[J]. J Neurosurg,2006,105(1):88-95.
    [10] Uzzaman M, Keller G, Germano IM. In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas[J]. Neuro Oncol,2009,11(2):102-8.
    [11] Fan CG, Zhang QJ. Application prospect of bone marrow mesenchymal stem cells in the treatment of glioma[J]. Zhongguo Zu Zhi Gong Cheng Yan Jiu,2012,16(41):7737-41. [范存刚, 张庆 俊. 骨髓间充质干细胞在脑胶质瘤治疗中的应用前景[J].中国 组织工程研究,2012,16(41),7737-41.]
    [12] Sasportas LS, Kasmieh R, Wakimoto H, et al. Assessment of therapeutic effi cacy and fate of engineered human mesenchymal stem cells for cancer therapy[J]. Proc Natl Acad Sci U S A,2009,106(12):4822-7.
    [13] Menon LG, Kelly K, Yang HW, et al. Human bone marrowderived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy[J]. Stem Cells,2009,27(9):2320-30.
    [14] Yang B, Wu X, Mao Y, et al. Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells[J]. Neurosurgery,2009,65(3):610- 24.
    [15] Fan CG, Zhou JR, Zhang QJ. The application prospects of human umbilical cord blood derived mesenchymal stem cells in brain glioma[J]. Guo Ji Shen Jing Bing Xue Shen Jing Wai Ke Xue Za Zhi, 2011,38(6):598-602. [范存刚, 周景儒, 张庆俊. 人脐带血来 源的间充质干细胞在脑胶质瘤治疗中的应用前景[J]. 国际神经 病学神经外科学杂志,2011,38(6), 598-602.]
    [16] Kim SM, Lim JY, Park SI, et al. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma [J]. Cancer Res,2008,68(23):9614-23.
    [17] Kim SM, Oh JH, Park SA, et al. Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord bloodderived mesenchymal stem cells in glioma therapy[J]. Stem Cells,2010,28(12):2217-28.
    [18] Fan CG, Zhang QJ. The potentials of human adipose tissue derived mesenchymal stem cells in targeted therapy of experimental glioma[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi,2012,12(6):651-4. [范存刚, 张庆俊. 人脂肪源性间充质干细 胞在实验性脑胶质瘤靶向治疗中的应用[J]. 中国现代神经疾病 杂志,2012,12(6),651-4.]
    [19] Choi SA, Hwang SK, Wang KC, et al. Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma[J]. Neuro Oncol,2011,13(1):61-9.
    [20] Fan CG, Wang DL, Zhang QJ,et al. The experimental investigation of glioma-trophic capacity of human umbilical cord-derived mesenchymal stem cells after intraventricular administration[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2013,13(7),620-7. [范存刚,王栋梁,张庆俊,等. 经侧脑室注射人脐带间充质干 细胞向胶质瘤趋化能力的实验研究[J]. 中国现代神经疾病杂 志,2013,13(7),620-7.]
    [21] Fan CG, Zhang QJ, Zhou JR. Therapeutic potentials of mesenchymal stem cells derived from human umbilical cord[J]. Stem Cell Rev,2011,7(1):195-207.
    [22] Unterkircher T, Cristofanon S, Vellanki SH, et al. Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis[J]. Clin Cancer Res,2011,17(12):4019-30.
    [23] Balyasnikova IV, Ferguson SD, Han Y, et al. Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts[J]. Cancer Lett,2011,310(2):148-59.
    [24] Kahana S, Finniss S, Cazacu S, et al. Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions[J]. Cell Signal,2011,23(8):1348-57.
    [25] Ding L, Yuan C, Wei F, et al. Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP[J]. Cancer Invest,2011,29( 8) :511-20.
    [26] Qiu B, Sun X, Zhang D, et al. TRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitro[J]. Int J Mol Sci,2012,13(7):9142-56.
    [27] Hingtgen S, Ren X, Terwilliger E, et al. Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide[J]. Mol Cancer Ther,2008,7(11):3575-85.
    [28] Yulyana Y, Endaya BB, Ng WH, et al. Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma[J]. Stem Cells Dev,2013,22(13): 18 70-82.
    [29] Corsten MF, Miranda R, Kasmieh R, et al. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas[J]. Cancer Res,2007,67(19):8994-9000.
    [30] Bagci-Onder T, Wakimoto H, Anderegg M, et al. A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem celldelivered TRAIL in experimental glioma models[J]. Cancer Res,2011,71(1):154-63.
    [31] van de Water JA, Bagci-Onder T, Agarwal AS, et al. Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects[J]. Proc Natl Acad Sci U S A,2012,109(41):16642-7.
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出版历程
  • 收稿日期:  2013-08-05
  • 修回日期:  2013-10-09
  • 刊出日期:  2014-02-24

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