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晚期非小细胞肺癌合并肺部感染的危险因素及相关性分析

苏 强, 马妮娜, 李 琴, 俞 静, 曹邦伟

苏 强, 马妮娜, 李 琴, 俞 静, 曹邦伟. 晚期非小细胞肺癌合并肺部感染的危险因素及相关性分析[J]. 肿瘤防治研究, 2014, 41(01): 31-34. DOI: 10.3971/j.issn.1000-8578.2014.01.008
引用本文: 苏 强, 马妮娜, 李 琴, 俞 静, 曹邦伟. 晚期非小细胞肺癌合并肺部感染的危险因素及相关性分析[J]. 肿瘤防治研究, 2014, 41(01): 31-34. DOI: 10.3971/j.issn.1000-8578.2014.01.008
SU Qiang, MA Ni'na, LI Qin, YU Jing, CAO Bangwei. Risk Factors of Advanced Non-small Lung Cancer with Pulmonary Infection[J]. Cancer Research on Prevention and Treatment, 2014, 41(01): 31-34. DOI: 10.3971/j.issn.1000-8578.2014.01.008
Citation: SU Qiang, MA Ni'na, LI Qin, YU Jing, CAO Bangwei. Risk Factors of Advanced Non-small Lung Cancer with Pulmonary Infection[J]. Cancer Research on Prevention and Treatment, 2014, 41(01): 31-34. DOI: 10.3971/j.issn.1000-8578.2014.01.008

晚期非小细胞肺癌合并肺部感染的危险因素及相关性分析

基金项目: 北京市“215”高层次卫生人才基金资助项目(2011-2014);北京市“十百千”人才基金资助项目(2011-2013)
详细信息
    作者简介:

    苏强(1978-),男,博士,主治医师,主要从事胸部实体恶性肿瘤的临床和基础研究

    通讯作者:

    曹邦伟,E-mail:daweicao@163.com

  • 中图分类号: R734.2

Risk Factors of Advanced Non-small Lung Cancer with Pulmonary Infection

  • 摘要: 目的 探讨晚期非小细胞肺癌(non-small cell lung cacer,NSCLC)合并肺部感染的危险因素。方法 通过回顾性临床研究的方法,收集2011年6月至2012年6月北京友谊医院肿瘤科收治107例住院非小细胞肺癌患者的临床资料,其中合并肺部感染患者33例,收集肺部感染的相关因素并进行统计。计数资料采用卡方检验,计量资料采用t检验进行分析,应用Logistic回归模型对非小细胞肺癌合并肺部感染的危险因素进行分析。结果 107例非小细胞肺癌患者中,男性70例,肺部感染发生率为27.1%(19/70),女性37例,肺部感染发生率为37.8%(14/37)。在诸多因素中,体温状态(P<0.01)、血清白蛋白水平(P=0.01)、化疗(P=0.01)、粒细胞缺乏(P=0.04),以及基础疾病的罹患等在肺部感染组和非感染组之间差异有统计学意义。结论 患者血清白蛋白水平降低、粒细胞减少、化疗、既往有糖尿病史等,均为晚期非小细胞肺癌合并肺部感染的主要危险因素。

     

    Abstract: Objective To investigate the risk factors of pulmonary infection within advanced NSCLC patients. Methods Retrospective clinical data of 107 NSCLC patients were collected from 2011 to 2012 in oncology department of our hospital. Thirty-three patients was suffered the pulmonary infection. The count data were analyzed using the chi-square test, the measurement data and the risk factors of pulmonary infection were analyzed using t test or logistic analysis,respectively. Results Of 107 patients with non-small cell lung cancer, 70 cases were male and 37 cases were female. The rate of pulmonary infection was 27.1% (19/70) in male and 37.8%(14/37) in female, respectively. The average age was 66.5 years old. From logistic analysis, the temperature, serum albumin level, chemotherapy, agranulocytosis,and accompanying diseases were exhibited signifi cant differences between the two groups. Conclusion In older patients with advanced NSCLC, the high temperature, low serum album level, agranulocytosis, and a history of diabetes were demonstrated as the major risk factors for pulmonary infection.

     

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出版历程
  • 收稿日期:  2012-10-21
  • 修回日期:  2012-12-30
  • 刊出日期:  2014-01-24

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