Abstract: Objective To evaluate the diagnostic value of liquid-based cytology in the pathological changes of endometrium. Methods Two hundred and sixty-eight cases of pathological changes of endometrium detected by liquid-based cytology in Longjiang and JunAn hospitals of ShunDe district from December, 2010 to December, 2012 were retrospectively analyzed. Pathologic diagnosis of liquid-based cytology, fractional diagnostic curettage or total hysterectomy was contrastively analyzed. Results The sampling satisfaction rate of liquid-based cytology of the 268 samples was 96.64% (259/268), among which, there was 241 cases of both liquid-based cytology and histology satisfi ed samples, Liquid-based cytology diagnosis showed that coincidence rates of no intraepithelial pathological changes, innocence hyperplasia pathological changes, atypical hyperplasia and endometrial cancer with histodiagnosis result were 86.84%(99/114), 85.23%(75/88), 76.92%(20/26), 84.62%(11/13) respectively. Conclusion Both the sampling satisfaction rate of endometrial liquid-based cytology and the coincidence rate of its consequence and histology pathologic diagnosis were very high. Thus the endometrial liquid-based cytology was a valuable diagnostic method for pathological changes of endometrium. Atypical hyperplasia was the diffi culty of endometrial liquid-based cytology.