乳腺癌磁共振特征与HER-2表达的相关性

杨 丽; 时高峰; 刘 辉; 周 涛

doi:10.3971/j.issn.1000-8578.2013.11.013

乳腺癌磁共振特征与HER-2表达的相关性

1. 050011石家庄, 河北医科大学第四医院CT/MR室，2. 乳腺中心

基金项目: 河北省高校强势特色学科基金资助项目(冀教高[2005]52号)

详细信息

作者简介:
杨丽(1980-)，女，硕士，主治医师，主要从事肿瘤影像诊断研究

中图分类号: R737.9；R445.2
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- 文章访问数: 1369
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出版历程
- 收稿日期: 2012-08-27
- 修回日期: 2013-03-03
- 刊出日期: 2013-11-24

Correlation on MRI Features and HER-2 Expression of Breast Cancer

1. Department of CT/MR, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China, 2. Department of Breast Center

摘要

摘要: 目的分析乳腺癌磁共振（MRI）形态学、早期强化率及表观扩散系数（ADC）与HER-2表达的相关性。方法对63例手术证实的乳腺癌患者的乳腺MRI特征与HER-2表达进行分析。观察乳腺癌MRI形态学特征，计算肿物早期强化率及ADC值，应用χ2检验及Spearman秩相关分析分析其与HER-2表达的相关性。结果乳腺癌肿有无坏死与HER-2高表达率有关，有坏死组高表达率较无坏死组明显增高，差异有统计学意义（χ2＝4.257，P＝0.039）。乳腺癌肿边缘是否光滑与HER-2高表达率无关（χ²＝0.100，P＝0.921）。乳腺癌早期强化率与HER-2表达水平无关（r＝0.159，P＝0.215）。乳腺癌ADC值与HER-2表达水平呈负相关（r＝-0.366，P＝0.003）。结论乳腺癌MRI征象可以从一定程度上反映肿瘤HER-2蛋白的表达水平。
- 乳腺癌 /
- 磁共振成像 /
- HER-2
Abstract: Objective To investigate the correlations among MRI morphologic feature, the early-phase enhancement rate, apparent diffusion coefficient (ADC) and HER-2 of breast cancer. Methods Sixtythree patients diagnosed as breast cancers by pathologic examination were reviewed, including MRI features and the expression of HER-2. The morphologic features were observed in early phase. The early-phase enhancement rate and the value of ADC were also calculated. All statistical analyses were performed by using SPSS11.5. Results In the cases with breast cancer, the high expression rate of HER-2 had correlation with necrosis, with higher overexpression rate in patients with necrosis than in the others(χ2＝4.257，P＝0.039). The high expression rate of HER-2 had no correlation with the margin(χ2＝0.100，P＝0.921). The expression rate of HER-2 had no correlation with the early-phase enhancement rate(r＝0.159，P＝0.215). The value of ADC had negative correlation with the expression rate of HER-2(r＝-0.366，P＝0.003). Conclusion MRI features can refl ect the expression of HER-2 in breast cancer partly.
- Breast cancer /
- Magnetic resonance imaging(MRI) /
- HER-2

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参考文献(12)

[1]	Xu BH. Breast Cancer[M].Beijing:Peking University Medical Press, 2005:15-8. [徐兵河.乳腺癌[M].北京:北京大学医学出版社, 2005:15-8.]
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乳腺癌磁共振特征与HER-2表达的相关性

作者简介:
杨丽(1980-)，女，硕士，主治医师，主要从事肿瘤影像诊断研究

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Correlation on MRI Features and HER-2 Expression of Breast Cancer

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乳腺癌磁共振特征与HER-2表达的相关性

作者简介: 杨丽(1980-)，女，硕士，主治医师，主要从事肿瘤影像诊断研究

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Correlation on MRI Features and HER-2 Expression of Breast Cancer

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作者简介:
杨丽(1980-)，女，硕士，主治医师，主要从事肿瘤影像诊断研究