整合素αvβ3在脑胶质瘤的表达与肿瘤恶性程度的关系

Correlation between the integrin αv3 expression and malignant degree of human gliomas

摘要: 目的探讨整合素 αｖβ３与脑胶质瘤恶性程度之间的关系。方法应用免疫组化ＳＡＢＣ法检测整合素 αｖβ３在４３例Ⅰ～Ⅳ级脑胶质瘤和ＢＴ３２５人胶质瘤细胞系中的表达。结果Ⅲ～Ⅳ级脑胶质瘤阳性率及高表达率均明显高于 Ⅰ～Ⅱ级脑胶质瘤（Ｐ＜０．０５）。结论整合素 αｖβ３与脑胶质瘤恶性程度呈正相关，并可能对胶质瘤的侵袭性起正性调节作用

Abstract: Objective To investigate the relation between integrin av133 and malignant degrcc of human gliomas. Methods Forty-three formalin-fixed sections glioma tissue and BT325 glioma cell line were ob- tained. The integrinαvβ3 subunit was measured with immunohistochemistry assay (SABC method). Re- suits Glioma tissue with poor differentiation expressed higherαvβ3 than those with good differentiation (P <0. 05), BT325 glioma cell line expressed integrinαvβ3. Conclusion Our stu...