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胃癌腹膜转移的治疗进展

谭伊诺, 袁瑛

谭伊诺, 袁瑛. 胃癌腹膜转移的治疗进展[J]. 肿瘤防治研究, 2015, 42(05): 506-510. DOI: 10.3971/j.issn.1000-8578.2015.05.019
引用本文: 谭伊诺, 袁瑛. 胃癌腹膜转移的治疗进展[J]. 肿瘤防治研究, 2015, 42(05): 506-510. DOI: 10.3971/j.issn.1000-8578.2015.05.019
TAN Yi'nuo, YUAN Ying. Treatment Advances of Peritoneal Metastasis from Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 506-510. DOI: 10.3971/j.issn.1000-8578.2015.05.019
Citation: TAN Yi'nuo, YUAN Ying. Treatment Advances of Peritoneal Metastasis from Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 506-510. DOI: 10.3971/j.issn.1000-8578.2015.05.019

胃癌腹膜转移的治疗进展

详细信息
    作者简介:

    谭伊诺(1990-),男,硕士,主要从事恶性肿瘤综合防治研究

    通讯作者:

    袁瑛,E-mail:yuanying1999@zju.edu.cn

  • 中图分类号: R735.2

Treatment Advances of Peritoneal Metastasis from Gastric Cancer

  • 摘要: 尽管胃癌的治疗策略和方法在不断进步,胃癌患者的预后在逐步改善,但胃癌腹膜转移患者的预后仍非常差,故需不断探索有效的治疗措施和药物。目前全身化疗仍是基础,常用药物有替吉奥(S-1)、紫杉类、铂类等,而腹腔灌注化疗中应用紫杉醇、顺铂、多西他赛等药物也有临床试验显示出一定的疗效。细胞减灭术联合腹腔热灌注化疗可在部分患者中有生存获益甚至获得长期生存。上皮细胞黏附分子EpCAM,腹膜转移普遍表达的靶点,其特异性单抗Catumaxomab可能在胃癌腹膜转移中具有应用前景。本文对胃癌伴腹膜转移的诊疗进展进行回顾总结。

     

    Abstract: Although the treatment of gastric cancer is advancing, the clinical outcome is gradually improving, the survival of gastric cancer patients with peritoneal metastasis is still very poor. Effective drugs and strategies against peritoneal metastasis are needed. Now, systemic chemotherapy is the basics, commonly used drugs include S-1, paclitaxel and platinum, etc.. Intraperitoneal chemotherapy with paclitaxel, platinum and docetaxel could also be effective. Cytoreductive surgery combined with intraperitoneal chemotherapy could bring some patients survival benefit, even long-term survival. Peritoneal metastatic lesions showed high levels of epithelial cellular adhesion molecule (EpCAM), an anti-EpCAM monoclonal antibody, Catumaxomab, may be effective against peritoneal metastasis from gastric cancer. In this paper, we review the treatment advances of peritoneal metastasis from gastric cancer.

     

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出版历程
  • 收稿日期:  2014-11-26
  • 修回日期:  2015-02-28
  • 刊出日期:  2015-05-24

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