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食管癌组织中microRNA-21的表达及其意义

向正凯, 严宝国

向正凯, 严宝国. 食管癌组织中microRNA-21的表达及其意义[J]. 肿瘤防治研究, 2014, 41(08): 902-905. DOI: 10.3971/j.issn.1000-8578.2014.08.010
引用本文: 向正凯, 严宝国. 食管癌组织中microRNA-21的表达及其意义[J]. 肿瘤防治研究, 2014, 41(08): 902-905. DOI: 10.3971/j.issn.1000-8578.2014.08.010
XIANG Zhengkai, YAN Baoguo. microRNA-21 Expression in Esophageal Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 902-905. DOI: 10.3971/j.issn.1000-8578.2014.08.010
Citation: XIANG Zhengkai, YAN Baoguo. microRNA-21 Expression in Esophageal Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 902-905. DOI: 10.3971/j.issn.1000-8578.2014.08.010

食管癌组织中microRNA-21的表达及其意义

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    通讯作者:

    严宝国,E-mail:baoguoy718@126.com

  • 中图分类号: R735.1

microRNA-21 Expression in Esophageal Cancer and Its Clinical Significance

  • 摘要: 目的 探讨microRNA-21(miR-21)在食管癌组织中的表达并分析其与临床病理因素之间的关系。方法 采用实时定量PCR方法检测72例食管癌组织和同一患者的邻近正常食管组织中miR-21的表达,并评估miR-21与临床病理因素之间的相关性。运用Kaplan-Meier和Cox回归分析方法对食管癌患者进行生存分析。结果 miR-21在肿瘤组织中的表达明显高于正常组织(P=0.001)。同时,miR-21的表达与肿瘤的TNM分期、病情恶化之间有明显的相关性(P=0.023,P=0.025)。另外, miR-21高表达的患者有着显著更差预后(P=0.004)。结论 miR-21可作为食管癌患者预后的一个指标,是治疗食管癌潜在的靶点。

     

    Abstract: Objective To investigate microRNA-21(miR-21) expression in esophageal cancer (EC) and its relationship with clinicopathological features. Methods Expression levels of miR-21 in 72 pairs of EC and adjacent normal tissues were detected by real-time quantitative RT-PCR assay, and the relevance between miR-21 and clinicopathological features was evaluated. Kaplan-Meier and Cox proportional regression analysis were performed to determine the association of miR-21 expression and survival of EC patients. Results miR-21 expression in EC tissues was significantly higher than that in adjacent normal tissues (P=0.001). There was a significant correlation between miR-21 expression and TNM stage, EC progression(P=0.023, P=0.025). In addition, EC patients with higher miR-21 expression had significantly poorer overall survival (P=0.004). Conclusion miR-21 may serve as a potent prognostic marker for tumor recurrence and survival of EC patients, and might be a promising target in the treatment of EC.

     

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出版历程
  • 刊出日期:  2014-08-24

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