高级搜索

胰腺癌组织中表皮生长因子受体、基质金属蛋白酶9的表达及其意义

魏礼清, 向春香, 刘水逸, 卢忠心

魏礼清, 向春香, 刘水逸, 卢忠心. 胰腺癌组织中表皮生长因子受体、基质金属蛋白酶9的表达及其意义[J]. 肿瘤防治研究, 2014, 41(07): 799-802. DOI: 10.3971/j.issn.1000-8578.2014.07.024
引用本文: 魏礼清, 向春香, 刘水逸, 卢忠心. 胰腺癌组织中表皮生长因子受体、基质金属蛋白酶9的表达及其意义[J]. 肿瘤防治研究, 2014, 41(07): 799-802. DOI: 10.3971/j.issn.1000-8578.2014.07.024
WEI Liqing, XIANG Chunxiang, Liu Shuiyi, LU Zhongxin. Expression and Significance of Epidermal Growth Factor Receptor and Matrix Metalloproteinase-9 in Pancreatic Carcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 799-802. DOI: 10.3971/j.issn.1000-8578.2014.07.024
Citation: WEI Liqing, XIANG Chunxiang, Liu Shuiyi, LU Zhongxin. Expression and Significance of Epidermal Growth Factor Receptor and Matrix Metalloproteinase-9 in Pancreatic Carcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 799-802. DOI: 10.3971/j.issn.1000-8578.2014.07.024

胰腺癌组织中表皮生长因子受体、基质金属蛋白酶9的表达及其意义

详细信息
    作者简介:

    魏礼清(1982-),男,硕士,主治医师,主要从事肿瘤生物学的研究

    通讯作者:

    卢忠心, E-mail:lzx71@yaohoo.com

  • 中图分类号: R735.9

Expression and Significance of Epidermal Growth Factor Receptor and Matrix Metalloproteinase-9 in Pancreatic Carcinoma Tissues

  • 摘要: 目的 探讨胰腺癌组织中表皮生长因子受体(EGFR)、基质金属蛋白酶9(MMP-9)的表达及其与胰腺癌临床病理特征的关系。方法 应用免疫组织化学SP法检测44例胰腺癌、相应癌旁胰腺组织、13例慢性胰腺炎和7例正常胰腺组织中EGFR、MMP-9的表达,并分析其与临床病理特征的相关性。结果 正常胰腺组织中均无EGFR及MMP-9的表达。慢性胰腺炎组织中EGFR、MMP-9的阳性表达率分别为23.1%(3/13)和15.4%(2/13)。胰腺癌组织中EGFR、MMP-9的阳性表达率分别为61.4%(27/44) 和54.5%(24/44);相应癌旁组织中的阳性表达率分别为34.1%(15/44)和29.5%(13/44)。胰腺癌组织中的EGFR及MMP-9阳性表达率均显著高于相应癌旁组织(P<0.05);胰腺癌组织及癌旁组织中EGFR及MMP-9的表达均显著高于慢性胰腺炎组织和正常胰腺组织(P均<0.05)。EGFR和MMP-9的表达与胰腺癌临床分期、分化程度、血管侵犯及淋巴结转移相关。结论 胰腺癌组织中EGFR的表达与MMP-9表达密切相关,EGFR的表达与MMP-9的表达水平可作为了解胰腺癌生物学行为和判断预后的指标。

     

    Abstract: Objective To discuss the expression of epidermal growth factor receptor (EGFR) and matrix metalloproteinase-9(MMP-9) in pancreatic carcinoma tissues, and its relationship with clinicopathologic features of pancreatic carcinoma. Methods Expression of EGFR and MMP-9 were detected by immunohistochemistry in surgically resected specimens(cancer tissues,cancer adjacent tissues and normal tissues)from 44 pancreatic carcinoma patients,13 chronic pancreatitis patients and 7 normal patients. The results were analyzed combined with clinicopathologic characteristics. Results There was no expression of EGFR or MMP-9 in normal pancreatic tissues.The expression of EGFR and MMP-9 in chronic pancreatitis tissues were 23.1%(3/13) and 15.4%(2/13).The expression of EGFR and MMP-9 in cancer tissues were higher than those in cancer adjacent tissues(61.4% vs. 34.1%,54.5% vs. 29.5%, P<0.05).Both expression of EGFR, MMP-9 in cancer tissues and adjacent tissues were significantly higher than those in tissues of normal pancreas and chronic pancreatitis(all P<0.05). There were positive correlation between EGFR,MMP-9 expression and superior mesenteric vessels invasion, lymph node metastasis, clinical stage, differentiation of tumor. Conclusion The expression of EGFR and MMP-9 are closely correlated in pancreatic carcinoma tissues, and could be the index for learning biological behavior and prognosis of pancreatic carcinoma.

     

  • [1] Brand TM,Iida M, Li C,et a1.The nuclear epidermal growth factor receptor signaling network and its role in cancer[J].Discov Med,2011,12(66):419-32.
    [2] Ardito CM, Grüner BM, Takeuchi KK,et a1.EGF receptor is required for KRAS-induced pancreatic tumorigenesis[J]. Cancer Cell,2012,22(3):304-17.
    [3] He XJ, Jiang XT, Ma YY, et a1.REG4 contributes to the invasiveness of pancreatic cancer by upregulating MMP-7 and MMP-9[J]. Cancer Sci, 2012,103(12):2082-91.
    [4] Fujisawa T, Rubin B, Suzuki A, et a1.Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer[J]. PLoS One. 2012,7(4):e34437.
    [5] Biswas DK, Cruz AP, Gansberger E,et a1. Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen receptor negative breast cancer cells[J]. Proc Natl Acad Sci U S A,2000,97(15):8542-7.
    [6] Sergeant G, Lerut E, Ectors N, et al.The prognostic relevance of tumor hypoxia markers in resected carcinoma of the gallbladder [J] Eur J Surg Oncol, 2011,37(1):80-6.
    [7] Buck E,Eyzagnirre A,Brown E,et al.Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in nonsmall- cell lung, pancreatic, colon, and breast tumors[J].Mol Cancer Ther, 2006, 5(11):2676-84.
    [8] Rocha-Lima CM, Soares HP, Raez LE,et al. EGFR targeting of solid tumors[J]. Cancer Control, 2007,14(3):295-304.
    [9] Chen WG,Long HM,Hou JQ, et al. Effects of gefitinib and small interfering RNAs targeting EGFR in the treatment of prostate cancer[J].Zhonghua Shi Yan Wai Ke Za Zhi, 2010,3(27):325-7, back insert 2.[陈卫国,龙慧民,侯建全,等.吉非替尼和靶向表皮 生长因子受体小干扰RNA治疗前列腺癌[J].中华实验外科杂 志,2010,27(3):325-7, 后插2页.]
    [10] Walsh N, Kennedy S, Larkin A,et al.EGFR and HER2 inhibition in pancreatic cancer[J]. Invest New Drugs, 2013,31(3):558-66.
    [11] Nagaraj NS, Washington MK, Merchant NB.Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth[J]. Clin Cancer Res, 2011, 17 (3):483-93.
    [12] Mysliwiec AG, Ornstein DL.Matrix metalloproteinases in colorectal cancer[J]. Clin Colorectal Cancer, 2002,1(4):208-19.
    [13] Liotta LA,Tryggvason K,Garbisa S,et a1.Metastatic potential correlates with enzymatic degradation of basement membrane collagen[J].Nature,1980,284(5751):67-8.
    [14] Lue HW, Yang X, Wang R,et a1.LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HBEGF shedding and EGFR-mediated ERK signaling[J]. PLoS One, 20 11,6(11):e27720.
计量
  • 文章访问数:  1065
  • HTML全文浏览量:  380
  • PDF下载量:  617
  • 被引次数: 0
出版历程
  • 刊出日期:  2014-07-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭