结直肠癌中miRNA基因及其靶基因多态性位点的研究进展

Study Advancement of MicroRNA and Its Target Gene Polymorphism and Colorectal Tumorigenesis

摘要: 结直肠癌是最常见的消化系统肿瘤之一。近年来的研究表明，miRNA在结直肠癌的发病过程起着重要的作用。由于单核苷酸多态性（SNPs）的存在，miRNA的结构和功能可能发生变化，从而影响结直肠癌的发病率。目前国内外对miRNA及其靶基因多态性与结直肠癌的关系研究不多。在本文中，我们将对结直肠癌中miRNA表达谱的改变、miRNA基因及其靶基因多态性与结直肠癌的关系及miRNA基因多态性对于结直肠癌的诊断、预后判断、预测疗效的应用前景等内容进行综述。

Abstract: Colorectal cancer(CRC) is one of the most common cancers worldwide. Recent years, some studies show that miRNAs contribute to the development of CRC. Single Nucleotide Polymorphisms (SNP) of miRNAs alos may be the risk of CRC due to change their structure and function.. In this review, alterations of miRNAs in CRC and the relation between SNPs in miRNAs and target sites and CRC risk would be showed. Furthermore, the SNPs in miRNAs may be useful in diagnose and prognosis of CRC and so on.