Expression and Clinicopathologic Significance of Integrin α6 in Gliobastoma multiforme
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摘要: 目的 检测胶质母细胞瘤（GBM）中Integrin α6的表达及其与患者预后和CD133表达的关系。 方法 免疫组织化学方法检测39例人胶质母细胞瘤组织和32例正常脑组织中Integrin α6和CD133的表达，分析Integrin α6与患者临床病理因素、预后和CD133之间的关系。 结果 Integrin α6蛋白在GBM组织中的表达明显高于正常脑组织(P＜0.01)，且与CD133蛋白表达呈明显正相关(P＜0.05)，与患者的年龄、性别、KPS评分、术后放化疗情况均无明显相关性，而与是否完整切除和肿瘤大小呈明显负相关。Integrin α6阳性表达的GBM患者总生存期明显短于Integrin α6表达阴性组(P＜0.05)。 结论 Integrin α6与GBM的发生、发展密切相关，且与肿瘤干细胞密切相关，检测Integrin α6的表达可能对判断胶质母细胞瘤的预后具有一定价值。
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关键词:
- 整合素家族成员 α6 /
- 胶质母细胞瘤 /
- CD133
Abstract: Objective To investigate the clinicopathological significances of Integrin α6 expression in Gliobastoma multiforme (GBM). Methods Integrin α6 expression was assessed in 39 cases of paraffin-embedded GBM and 32 cases of normal samples by immunohistochemistry. Medical records were reviewed and the clinicopathological characteristics or outcomes were evaluated. Furthermore, we examined the association of the Integrin α6 expression with the CD133 expression, which was a marker of glioblastoma stem cells (GSCs). Results Integrin α6 expression was significantly higher in GBM than in normal brain tissue (P<0.01). Integrin α6 was positively correlated with the expression of CD133 (P<0.05) and negatively correlated with the tumor size and subtotal resection and had no significant relationship with patients' age, gender, KPS assessment and postoperative radiochemotherapy. For the patients with positive Integrin α6 expression in GBM, their overall survival time was obviously shorter than those with negative expression (χ2=4.388,P<0.05). Conclusion The overexpression of Integrin α6 is linked to GBM development and progression and is significantly correlated with GSCs. Hence, the expression levels of Integrin α6 is an useful indicators for the clinical assessment of tumor biological behavior in patients with GBM.-
Key words:
- Integrin α6 /
- Gliobastoma multiforme /
- CD133
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