高级搜索

SPARC蛋白在食管鳞癌组织中的表达及临床意义

杨锡贵, 姜超, 刘封, 杨香山

杨锡贵, 姜超, 刘封, 杨香山. SPARC蛋白在食管鳞癌组织中的表达及临床意义[J]. 肿瘤防治研究, 2012, 39(10): 1240-1242. DOI: 10.3971/j.issn.1000-8578.2012.10.019
引用本文: 杨锡贵, 姜超, 刘封, 杨香山. SPARC蛋白在食管鳞癌组织中的表达及临床意义[J]. 肿瘤防治研究, 2012, 39(10): 1240-1242. DOI: 10.3971/j.issn.1000-8578.2012.10.019
Yang Xigui, Jiang Chao, Liu Feng, Yang Xiangshan. SPARC Protein Expression and Clinical Significance in Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(10): 1240-1242. DOI: 10.3971/j.issn.1000-8578.2012.10.019
Citation: Yang Xigui, Jiang Chao, Liu Feng, Yang Xiangshan. SPARC Protein Expression and Clinical Significance in Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(10): 1240-1242. DOI: 10.3971/j.issn.1000-8578.2012.10.019

SPARC蛋白在食管鳞癌组织中的表达及临床意义

详细信息
    作者简介:

    杨锡贵(1958-),男,本科,研究员,主要从事肿瘤内科治疗工作

  • 中图分类号: R735.1

SPARC Protein Expression and Clinical Significance in Esophageal Squamous Cell Carcinoma

  • 摘要: 目的 探讨酸性富含半胱氨酸分泌型蛋白(SPARC)在食管鳞癌组织中的表达及临床意义。方法免疫组织化学法检测200例食管鳞癌及癌旁组织中SPARC蛋白的表达,分析其与食管癌患者临床特征的关系。结果200例食管癌标本162例表达(+/++),38例表达(-)。所有癌旁正常组织均表达(-),两者差异有统计学意义(P<0.01)。SPARC蛋白阳性表达颗粒大都定位于细胞间质、仅21例标本SPARC蛋白阳性表达颗粒可见于食管癌细胞的细胞质。食管癌组织中SPARC蛋白的表达与分期、转移相关,差异有统计学意义(P<0.05)。分期越晚,SPARC蛋白阳性表达率越高。在有转移的患者SPARC蛋白阳性表达率高;与性别、年龄、分化程度、浸润深度、相关生活习惯(饮酒、喜食腌制食品等)、家族史等均无相关性,差异无统计学意义(P>0.05)。结论食管癌组织中SPARC蛋白的表达可作为预测食管鳞癌分期、转移的指标之一。

     

    Abstract: Objective To investigate the role of secreted protein acidic and rich in cysteine(SPARC)in invasion,metastasis of esophageal squamous cell carcinoma(ESCC). Methods The differential protein expression of SPARC between esophageal squamous cell carcinoma and its corresponding normal esophageal mucosa was detected by immunohistochemistry(IHC) analysis.And the relationship between the expression of SPARC and invasion,metastasis was analyzed. Results Positive expression(+/++) of SPARC protein was detected in one hundred sixty-two cases, and negetive expression(-) was detected in 38 cases.The expression of SPARC protein was significantly upregulated in ESCC compared to that in corresponding normal esophageal mucosa(P<0.01).SPARC was positive expression in tumor stromal in most cases.High levels of SPARC in tumor cytolymph could be seen in few cases(21 cases).And the immunoactivity was detected mainly in the cancer cells localized at the tumor-stroma interface.SPARC protein expression and stage,metastasis was correlated significantly(P<0.05).The SPARC protein expression was higher in patients with later stages metastasis,and was not related with gender,age,differentiation,depth of invasion,related habits (drinking,eating pickled foods,etc.),family history,etc(P>0.05). Conclusion SPARC expression as a marker can be used to predict stage and metastasis of ESCC.

     

  • [1] Podhajcer OL,Benedetti L,Girotti MR,et al.The role of the matricellular protein SPARC in the dynamicinteraction between the tumor and the host[J].Cancer Metastasis Rev,2008,27(3):523-37.
    [2] Nagaraju GP,Sharma D.Anti-cancer role of SPARC,an inhibitor of adipogenesis[J].Cancer Treat Rev,2011,37(7):559-66.
    [3] Witkiewicz AK,Freydin B,Chervoneva I,et al.Stromal CD10 and SPARC expression in ductal carcinoma in situ(DCIS) patients predicts disease recurrence[J].Cancer Biol Ther,2010,10(4):391-6.
    [4] Xue LY,Hu N,Song YM.Tissue microarray analysis reveals a tight correlation between protein expressionpattern and progression of esophageal squamous cell carcinoma[J].BMC Cancer,2006,6:296.
    [5] Che YQ,Wang H,Qi J,et al.The analysis of the SPARC protein expression and clinical significance inesophageal squamous cell carcinoma[J].Zhongguo Zhong Liu Lin Chuang,2006,33(2):61-3.[车秩群,王海,齐军,等.食管鳞癌组织中SPARC蛋白表达的临床意义[J].中国肿瘤临床,2006,33(2):61-3.]
    [6] Nagai MA,Gerhard R,Fregnani JH,et al.Prognostic value of NDRG1 and SPARC protein expression in breast cancerpatients[J].Breast Cancer Res Treat,2011,126(1):1-14.
    [7] Luo KJ,Hu Y,Wen J.et al.CyclinD1,p53,E-cadherin,and VEGF discordant expression in paired regional metastaticlymph nodes of esophageal squamous cell carcinoma:A tissue array analysis[J].J Surg Oncol,2011,104(3):236-43.
    [8] Piao JM,Kim HN,Song HR,et al.p53 codon 72 polymorphism and the risk of esophageal cancer:a Korean case-control study[J].Dis Esophagus,2011,24(8):596-600.
    [9] Jiang DK,Yao L,Wang WZ,et al.TP53 Arg72Pro polymorphism is associated with esophageal cancer risk:a meta-analysis[J].World J Gastroenterol,2011,17(9):1227-33.
    [10] Umar M,Upadhyay R,Khurana R,et al.Role of p53 and p73 genes polymorphisms in susceptibility to esophagealcancer:a case control study in a northern Indian population[J].Mol Biol Rep,2012,39(2):1153-62.
    [11] Tanaka K,Yano M,Motoori M,et al.CEA-antigen and SCC-antigen mRNA expression in peripheral blood predicthematogenous recurrence after resection in patients with esophageal cancer[J].Ann Surg Oncol,2010,17(10):2779-86.
    [12] ukaszewicz-Zajac M,Mroczko B,Kozowski M,et al.Elevated levels of serum metalloproteinase 9 in patientswith esophageal squamous cell carcinoma[J].Pol Arch Med Wewn,2009,119(9):558-63.
    [13] Yi Y,Li B,Wang Z,et al.CYFRA21-1 and CEA are useful markers for predicting the sensitivity tochemoradiotherapy of esophageal squamous cell carcinoma[J].Biomarkers,2009,14(7):480-5.
    [14] Dong J,Zeng BH,Xu LH,et al.Anti-CDC25B autoantibody predicts poor prognosis in patients with advancedesophageal squamous cell carcinoma[J].J Transl Med,2010,8:81.
计量
  • 文章访问数:  2675
  • HTML全文浏览量:  24
  • PDF下载量:  569
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-10-23
  • 修回日期:  2012-03-21
  • 刊出日期:  2012-10-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭