HER2-neu表达与胃癌预后关系的Meta分析

郑刚; 王舒艺; 熊斌

doi:10.3971/j.issn.1000-8578.2011.10.021

HER2-neu表达与胃癌预后关系的Meta分析

Meta-analysis on Association of HER2-neu Expression with Prognosis in Gastric Cancer

摘要

摘要: 目的探讨肿瘤组织中HER2-neu表达与胃癌预后的相关性。方法计算机检索相关文献，运用Meta分析方法对纳入文献进行综合定量分析。计算合并相对危险比（HR）和95%可信区间（95% CI）。结果入选文献20篇，包括患者总数为4 398例。有单因素分析结果的文献16篇，一致性检验Q值为27.48（P=0.025），合并HR为1.57（95%CI 1.30～1.90）；合并多因素分析结果的文献5篇，一致性检验Q值为4.03（P=0.401），合并HR为1.30（95%CI 1.09～1.52）。结论HER2-neu是胃癌预后不良的一个生物标志物。

Abstract: ObjectiveTo evaluate the prognostic significance of HER2-neu overexpression in gastric cancer. MethodsInvestigations between HER2-neu status and survival were identified by published studies.Pooled hazard ratio (HR) and its 95% confidence interval (95%CI) were calculated to evaluate the risk of disease. Results A total of 20 studies were analyzed by Meta-analysis method, including cumulative 4 398 cases.Pooling data from 16 studies of univariate analysis showed worse survival of patients with HER2-neu(+) (pooled HR=1.57, 95%CI 1.30～1.90),and maintained in 5 studies of multivariate analysis(pooled HR=1.30, 95%CI 1.09～1.52).The analysis for heterogeneity(Q statistic test) for 16 studies of univariate analysis showed they had heterogeneity(Q=27.48,P=0.025),but for 5 studies of multivariate analysis showed little heterogeneity(Q=4.03,P=0.401). Conclusion HER2-neu overexpression is a worse and independent parameter for overall survival of gastric cancer.

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