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甲状腺乳头状癌中CD44v6和p16基因表达的原位杂交研究

谷化平, 尚培中, 周翠玲

谷化平, 尚培中, 周翠玲. 甲状腺乳头状癌中CD44v6和p16基因表达的原位杂交研究[J]. 肿瘤防治研究, 2002, 29(06): 450-451. DOI: 10.3971/j.issn.1000-8578.2799
引用本文: 谷化平, 尚培中, 周翠玲. 甲状腺乳头状癌中CD44v6和p16基因表达的原位杂交研究[J]. 肿瘤防治研究, 2002, 29(06): 450-451. DOI: 10.3971/j.issn.1000-8578.2799
GU Hua-ping, SHANG Pei-zhong, ZHOU Cui-ling. Expression of CD44v6 and p16 gene in papillary thyroid carcinoma studied by in situ hybridization[J]. Cancer Research on Prevention and Treatment, 2002, 29(06): 450-451. DOI: 10.3971/j.issn.1000-8578.2799
Citation: GU Hua-ping, SHANG Pei-zhong, ZHOU Cui-ling. Expression of CD44v6 and p16 gene in papillary thyroid carcinoma studied by in situ hybridization[J]. Cancer Research on Prevention and Treatment, 2002, 29(06): 450-451. DOI: 10.3971/j.issn.1000-8578.2799

甲状腺乳头状癌中CD44v6和p16基因表达的原位杂交研究

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    通讯作者:

    谷化平

  • 中图分类号: R736.1

Expression of CD44v6 and p16 gene in papillary thyroid carcinoma studied by in situ hybridization

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    Corresponding author:

    GU Hua-ping

  • 摘要: 目的 探讨CD4 4v6和 p16基因表达与甲状腺乳头状癌 (PTC)侵袭转移的关系。 方法 应用原位杂交方法, 检测 4 6例PTC组织中CD4 4v6和 p16的mRNA表达。 结果 PTC组织中CD4 4v6和 p16的mRNA表达阳性率分别为 76 .1%和 6 0 .9%, 均与PTC侵袭转移相关 (P <0 .0 5 ) ;CD4 4v6mRNA与 p16mRNA表达呈负相关 (r = 0 .36, P <0 .0 0 5 )。结论 CD4 4v6和 p16基因表达可作为判断PTC预后的参考指标。

     

    Abstract: Objective To investigate the correlation of CD44v6 and p16 gene expression with the potential of invasion and metastasis in papillary thyroid carcinoma(PTC). Methods In situ hybridization method was used to detect CD44v6 mRNA and p16 mRNA expression in 46 cases of PTC. Results The positive rates of CD44v6 mRNA and p16 mRNA in PTC were 76.1% and 60.9% respectively.There was a positive correlation between CD44v6 mRNA expression and tumor invasion and metastasic potential in PTC( P <0.05),and a reverse c...

     

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出版历程
  • 收稿日期:  2002-01-27
  • 修回日期:  2002-04-11
  • 刊出日期:  2002-11-04

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