Abstract: Objective To analyze the correlation between miR-155 expression and serum CEA levels in colon carcinoma, and to explore its value in forecast of recurrence and metastasis after operation. Methods miR-155 expressions in 84 specimens of colon carcinoma and their matched adjacent tissues were examined by RT-PCR, and preoperative serum CEA levels were tested at the same time. The follow-up visit lasted for 2 years after operation and serum CEA levels were tested every two months. Results miR-155 expression was 4.03±2.95 in colon carcinoma, which was signifi cantly higher than that in adjacent normal tissues (P<0.05). miR-155 expression in colon carcinoma was signifi cantly and positively correlated with preoperative serum CEA levels(P<0.01). miR-155 expression in colon carcinoma was significantly and negatively correlated with the time of serum CEA re-increasing after operation(P<0.01). miR-155 expression in recurrence and metastasis group was signifi cantly higher than that in non-recurrence or metastasis group(P<0.05). The time of serum CEA re-increasing was significantly correlated with recurrence and metastasis after operation. Conclusion miR-155 expression is up-regulated obviously in colon carcinoma. Detection of miR-155 expression and serum CEA levels before and after operation together can offer more accurate information for diagnosis and prognosis of colon carcinoma, especially for recurrence and metastasis after operation.