Abstract: With the shift toward patient-centered care in oncology, the synergy between Shared Decision-Making (SDM) and Multidisciplinary Team Treatment (MDT) has become a key factor in optimizing clinical oncology practice. This article analyzes the core concepts and complementary relationships between SDM and MDT, and explores how their integration enhances the quality of cancer care and patient outcomes. SDM emphasizes patient involvement in cancer treatment decisions by integrating medical expertise with patient values to achieve personalized care, while MDT provides evidence-based and standardized comprehensive solutions through multidisciplinary collaboration. Their synergy is reflected in information exchange and complementary perspectives: MDT provides precision medicine support for SDM, whereas SDM refines MDT decisions through feedback on patient preferences. Clinical practice has shown that the combination of SDM and MDT improves the rationality of cancer treatment plans, patient adherence, and satisfaction, while strengthening physician-patient communication and trust, thereby facilitating the implementation of the biopsychosocial medical model in cancer prevention and treatment. Nevertheless, challenges such as limited medical resources, time constraints, and cognitive differences in cancer care remain, which require responses through resource optimization, process improvement, and targeted training. In the future, the application of information technology will further enhance the precision and efficiency of this synergy, offering more scientific and humanistic solutions for cancer prevention and treatment.