Clinicopathologic, Mucin Histochemical and CEA Immunohistochemical Study in Adenocarcinoma of the Bladder

Clinical and pathologic feature in 18 adenocarcinomas of the bladder were discussed. Sixteen cases wer.primary adenocarcinoma and the other 2 that of the metastasis. There were 14 males and 4 females. Their age ranged from 4o to 71with an average of 54 years. The clinical symptoms were non-particularity, except of discharge mucin urine to suggested mucinous carcinoma. Noeplasm alone resection was carried out for 6 of 16 primary adenocarcinomas, and partial cystectomy was carried out for the other 10.Total of 5-year survial rate of adenocarcinoma of the bladder was 33%.Histomorphology of adenocarcinoma of the bladder could be classified into two types:1.pure type,14 cases (tubular adenocarcinoma,8 cases;papillary adenocarcinoma, 4 cases;and mucinouscarcinoma,2 cases);2.Mixed type,4 cases (adenocarcinoma mixed with transitional cell carcinoma).Follow-up data showed that the patients prognosis of mixed type tumor were better than the pure type. Mucin histochemical staining confirmed that sialomucins predominatde over neutral mucins for adenocarcinoma of the bladder. Our study suggested also that CEA immunohistochemical staining was significant to estimate prognosis for adenocarcinoma of the bladder.