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Xie Yuanfeng, Wu Jinsheng, Yao Xiu, . The Difference of P16 Gene' s Aberrant Methylation Rate Between Colon Cancer and Normal Colonic Mucosa[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 111-113.
Citation: Xie Yuanfeng, Wu Jinsheng, Yao Xiu, . The Difference of P16 Gene' s Aberrant Methylation Rate Between Colon Cancer and Normal Colonic Mucosa[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 111-113.
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The Difference of P16 Gene' s Aberrant Methylation Rate Between Colon Cancer and Normal Colonic Mucosa

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  • The methylation rate of P16 gene in colon cancer cell lines, colonic cancer tissue and norm al colonic mucosa were examined by Southern blot method. T he data showed that aberrant methylation of 5' CpG island of P16 gene was observed in5 of 6(83.3%)colon cancer cell lines, 13 of 18(72. 2%)colon cancer tissue.In contrast,only 5 of 18(27.8%)normal colonic mucosa showed aberrant methylation of the 5'CpG island of P16 gene.The results suggest that P16 gene in colon cancer was inactivated by aberrant methylation.This can provide a new tactics and a new target for colon's gene therapy.
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