Advanced Search
Song Shumei, Mao Yongrong, Zhou Jinan, Zhang Xianlin. Expression of P-qP in Hepatic Pathological Lesions and its Biological Significance[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 96-97.
Citation: Song Shumei, Mao Yongrong, Zhou Jinan, Zhang Xianlin. Expression of P-qP in Hepatic Pathological Lesions and its Biological Significance[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 96-97.
shu

Expression of P-qP in Hepatic Pathological Lesions and its Biological Significance

  • Hubei Cancer Institute. Wuhan 430079

More Information
    Graphical Abstract
    • Abstract
  • Using S-P Immunohistochemical methods with micr+ray restoring tissue antigen, we examined the expression of P-qP in 22 primary hepatocarcinoma( PHC)，10 hepatic spongyvascular tumors, 11cirrhosis and 11 normal hepatic tissues. Among samples analysized, P-qP positive was detected in 19(86%)of 22 PHC, 5 of 11 in cirrhosis; P-qP showed minimal and mid positive in 11 normal tissues,while P-qP dyeing in hepatic pathological lesions were different: positive granute of hepatocellular carcinoma(HCC) is mainly in cell menbrane; In M-PHC, Gland cavity endo-menbrance was positive; Cell menbrance,cytoplasm of cirrhosis were min-mid positive;While location of positive granule is cytoplasm in normal hepatic cells, no positive granule in cell menbrance. These results show expression of P-qP in hepatic pathological lesions not only can judge the sensitivity of chemotherapy for cancer Patients, but also the location and intensity of P-qP expression might relate with the development of hepatocarcinoma.
    • FullText(HTML)
    • References (3)
  • [1]
    Cheng cheng Huang,et al.Overexpression of the MDR1 gene and P-Glycoprotein in Hepatocellular Carcinoma.J.NCI.1992,84(4):262-263.
    [2]
    Fojo.A.T, et al.L,xpression of a multidrug resistance gene in human tumors and tissues.Proc.Natl.Acad.Sci.CSA.1997.84:265-269.
    [3]
    Yasuo Kuwazuru, et al.Expression of the mukidrug transporter, P-qP, in acute leukemia cell and correlation to clinical drug ressistance.Cancer. 1990,66:868-873.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (1176) PDF downloads (326) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits：12186132 Visits today：9175

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return