ANTITUMOR ACTIVITY AND TOXICITY OF PAECILOMYCES SINENSIS SP. NOV.(Cn80-2)

Cn80-2 is a new species of Paecilomyces,ip 20-25mg/kg 7-10d.markedly prolinged the survival time of leukemia L1210 and P388 bearing mice, and limted the development of Lewis lung carcinoma in C57BL mice, but had no effect on EAC acd S180. In vitro,Cn80-2 caused a direct lethal cytotoxicity on Hela cells, IC50 was 1.25mg/ml. After treated with Cn80-2,the cells did not growth in immuno-nhibition mice to form cancer. Radioautography study showed that when Hela cells were labelled with H-TdR, the average grain counts per cell revealed that the synthesis of DNA was inhibited by Cn80-2.