THE PRELIMINARY OBSEY VATION OF THE INDUCTION OF THE LUNG CANCER AND MALIGNANCIES OF LOCAL INJECTION REGION BY N-METHYL-N'-NITRO-N-NITROSO GUANDINE IN MICE

The N-METHYL-N'-NITRO-N-NITROSO guanidine(MNNG) solution was given by suncutaneous and intramuscelar injections in LACA mice. Theinduction rates of lung adenocaarcinoma by the both kinds of injection were 85.71% within 351 days.But the injected rates of the malignancies of the local regions were 85.71% and 42.85% respectively.There was no tumor induced of control group whicn without MNNG injection. This is siple,ealiable method to induce the experimental lung adenocarcinoma model in mice.So MNNG is not only a local ragion carcinogen, but also a strong carcinogenic sunstance for inducing lung cancer.