The Antitumor Effect, Toxicity Of A New 5-FU Derivative FU-O-G And The Relation Between The Antitumor Effect With Glucose And β-Glucuronidase

In this paper we have discovered that the new 6-FU derivative FU-O-G had obvious antitumor effect on EAC, S₁₆₀,H₂₂, L₆₁₅ and L₁₂₁₈ in mice,The inhibitory tumor rate of FU-O-G could be markedly elevated by oral 5g/kg glucose during glucose was administed before 30 minuts.Glucose might decrease the PH and increase the activity of β-glucuronidase(β-G) in tumor tissues, The results helpful promoted hydrolysis of FU-O-G in tumor and released to 5-FU,Using a colorimetric method determining the activity of β-G in tumor tissues was much higher than that of other organ，or serum, except for colon and rectum.