Value of Immunhistochemical Investigatinn of Anti-GST-π Antibody in the Early Diagsis of the Gallbladder Carcinom

Human placental form of giutathione S-transferase (GST-π) was detected in38 gallbladder carcinoma and 24 atypical hyperplasis by Avindin biotin peroxidase complex (ABC) method using anti-GST-π antibody. of 22 normal gallbladder mucosa, 91% were negating for GST-π atain, 95% of 21 well and moderately differentialed gallbladder adenocarcinomas,all of poorly differentiated gallbladder adenocarcinomas, 75% of undifferentiated gallbladder Carcinomas, 100% of atypical hyperplasis were positive for GST-π stain. These results indicate that GST-π is a new sensitive marker for immunohistochmical detection of gallbladder carcinoma.