Ondansetron in the Prophylaxis of Cisplatin-Induced Nausea and Vomiting Phase Ⅱ clinical study report

Abstract Fourty-three cases with solid tumors were treated with cisplatin chemotherapy.we designed a regimen of use of Ondansetron (made,in chiaa) and metoclopramide in the prophylaxis of cisplatin induced mausea and vomiting. A total of 43 cases were rolled in the cross-over study.The anti-nausea and vomiting effect of Ondanseton was better than Metoclopramide.In the prophlaxis of vomitding CR+PR of the regimen of Ondansetron was 81.4% and 58.1% on day 1 and day 2, respectively. The regimen of Metoclopramide was 27.9% and 32. 6%, respectively. The results indicate that Ondansetron (made in china) is as good as Zofran in controling cisplatin-induced emesis,especially in acute emesis.It can replace Zofran.