Extensive Infiltration in Remission-inducing Therapy of Acute Promyelocytic Leukemia by Ratinoic Acid-Report Two Cases

In the remission-inducing therapy of two cases of acute promyelocytic leukemia with all-trans retinoic acie, leukemic infiltration around the punture site and edema in face and extremities appeared, paralleled to the elevation of peripheral white blood cell count. The signs gradually disappeared as the disease was controlled. its pathogenesis and management were discussed.