High Dose Carboplatin Therapy with Autologous Bone MarrowTrasplantation for Small Cell Lung Cancer

The efficacy of high dose carboplatin therapy with auotologous bone marrow transplantation(ABMT)was studied in five patients with extensive small cell lung cance (SCLC). Among of them, 4 males and 1 female, the average.age was 40. 6 years (range, 19 to 55 years), the median durationfrom dignosis to ABMT was approximately 8. 6 months (range, 3 to 14 months). Four patients hadreceived prior induction chemotherapy and one patient received the surgical therapy. At the begin-ing of high dose therapy, 3 patients had achived partial remission (PR) and other patients had notresponded to routine chemotherapy. The dose of carboplatin ranged from 560 to 1375 mg/mZ. Atthe end of high dose carboplatin therapy with ABMT, there were 4 complete remission (CR) andone case was not changed. The duration of CR ranged from 1. 5 to 18 months