Carcinogenesis of DNP on I-Iuman Embro Nasopharyngeal Mucosa Transplants in Nude Mice

Human embro nasopharyngeal mucosa tissues which had been subcutaneously transplanted into nude mice remained their primary structure and function. Based on this experimental model, N'Ndinitrosopiperazine (DNP) was used to induce the transplant mucosa epithelia into cancerous lesion.The experiments had four groups:once DNP administered group (11 case); low dose serial DNP administered group (12 cases); large dose serial DNP administered group (12 case); large dose serial DNP and PEA administered group (11 cases). The result showed that within 40 weeks, there were atypical hyperplasia (5, 6, 5, 4 cases separately); carcinoma in situ (3, 1, 1, 1 cases separately); infiltrating carcinoma (1 case in large dose serial DNP and PMA administered group).