Applied value of cytokeratin in the detection of neoplastic trophoblasts

The expression of cytokeratin in 129 trophoblastic tumors was studied immunohistochemically using an antibody against broad spectrum cytokeratin. The results showed that the positive rate of neoplastic syncytiotrophoblast (ST) ; intermediate trophoblast (IT) and cytotrophoblast (CT) was 100% respectively. The expression of ST showed strong positive, and plasma type; the expression of IT was middle to strong positive,most of IT was plasma type; the expression of CT appeared middle positive, and plasma membrane type. We beliyed that cytokeratin was a sensitive and reliable marker for neoplastic trophoblasts (including metastatic tumor), and had important value for pathological diagnosis, deferred diagnosis and determination of infiltrating range of trophoblastictumors.