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Chen Zhendong, . Medroxyprogesterone Acetate with Antiemetics: Efficacy in ControllingAnorexia, Nausea and Vomiting Induced by Chemotherapy[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 102-103.
Citation: Chen Zhendong, . Medroxyprogesterone Acetate with Antiemetics: Efficacy in ControllingAnorexia, Nausea and Vomiting Induced by Chemotherapy[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 102-103.
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Medroxyprogesterone Acetate with Antiemetics: Efficacy in ControllingAnorexia, Nausea and Vomiting Induced by Chemotherapy

  • Department of Medical oncology, First Attached Hospitalof Anhui Medical University, Hefei 230022

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  • Anorexia,nausea and vomiting are common chemotherapy complications.Though the vomiting could be controlled with antiemitics generally,the anorexiaand nausea have not been dealed with successfully. This paper was developed toobsere the efficacy of Medroxyprogesterone Acetaote(MPA)in preventing thecomplications.The result showed that unchanged or improved appetite after chemotherapywas 73% in the MPA patients and 19% in the control group(P0. 005). No nausea occurrence was 63% and 29% respectivelyly (P0. 05). If anorexia was complained by the MPA patients.the strength andlength were less obviously than the control group. There did not have significant difference in controling the vomiting with MPA addition. Transient mild edema wasobserved in the MPA group.It is concluded that MPA with antiemetics can prevent better the anorexia andnausea induced by chemotherapy than antiemetics only.
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    • References (5)
  • 1. Gralla RJ. et al. The management of chemotherapy-in-duced nausea and vomiting. Med Clin N Am, 1987,71:289.
    2. 陈振东，胡小龙，方式.口服胃复安和地塞米松控制CINV.肿瘤防治研究，1993,20:273.
    3. Nelson KA, et al. The cancer anirexia-cachexia syn-drome. J Clin Oncol, 1994, 12:213.
    4. 陶旭光，等.单尺度方法在慢性病学研究中的应用.中国慢性病预防与控制，1992,149.
    5. Bernstein J，Learned taste aversions in children receiv-ing chemotherapy. Science, 1978,209:416.
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