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Wu Wensen, . The Effect of Female hormones in stopping growth of MNU-induced Urinary bladder tumors in Rats and reducing the size of tumors in Mice[J]. Cancer Research on Prevention and Treatment, 1996, 23(1): 4-7.
Citation: Wu Wensen, . The Effect of Female hormones in stopping growth of MNU-induced Urinary bladder tumors in Rats and reducing the size of tumors in Mice[J]. Cancer Research on Prevention and Treatment, 1996, 23(1): 4-7.

The Effect of Female hormones in stopping growth of MNU-induced Urinary bladder tumors in Rats and reducing the size of tumors in Mice

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  • Spayed Wistar rats were given 0. 5mg MNU per week for 4 weeks, administered intravesicular. Estradol Valerate or restosterone Proprionate were then injected intramuscularly into the gonadectomied animals weekly for a period of 20 weeks,Estradiol Valerate was seen to have the effect of controlling tumor growth whileTestosterone Proprionate accelerated tumor growth. Further experimentsdemonstrated that Estradiol Benzoate, Estradiol Valerat, Diethystilbestrol, Megestrol and Progesterone are effective in treating tumor types BST 739 and BTT739 inmice.
  • 1. 顾方六.任月娟.膀胧肿瘤的治疗及远期疗效.中华泌尿外科杂志,1982, 3(1):46
    2. Beatram J. S, Craig A. W: specific induction of bladder cancer in mice by butyl-(4-hydroxybutyl)-nitrosamine and effects of hormonal modification on the sex differ-encein response. Europ. J cancer, 1972.8:587.
    3. 武文森,尹克铮,张荣久,等.BBN诱发大鼠膀胧肿瘤实验研究.肿瘤防治研究,1993,20(1):23
    4. Okajima E, Hiramatsu. T, Iriya, k:Effects of sex hor-mones on development of Urinary bladder tumours in rats induced by N-butyl-N-< 4-hydroxybutyl )-ni-trosamine. Urol Res, 1975,3:75.
    5. yoshida, o; Erturk, E; Bryan (U. T. et al:The effect of gonadectomy and hormone odministration on the Uri-nary bladder carcinogenicity of N-[4-(5-vitro-2-furyl)-2-thiazolyl}-formanide in male and female suiss mice.Invost, Urol. 1973,11:26.
    6. 武文森,尹克铮.BBN诱发小鼠膀肤肿瘤及可移植性膀胧癌株(BST739)的建立及其特性研究.南京铁道医学院学报,1992,11(1):12
    7. 武文森,尹克铮,韩月明,等.小鼠膀肤移行细胞癌可移植模型BTT739)的建立及实验研究.中华医学会一九九三年度全国病理学术会议论文摘要汇编.1993. 136.
    8. 抗癌药物体内药效试验规程.第三届全国肿瘤药理及化疗学术会议.1989.
    9. Melicow M. M. Uson A. C. And Lipto. R;glucoro-nidase activity in the Urine of patients with bladder cancer and other conditions. J Urol,1961,86:89.
    10 李世文,邓昊照,唐孝达,等.膀胧移行细胞癌雄激素受体研究.中华泌尿外科杂志,1993,14(5):363.
    11 刘长吉.人癌细胞培养在泌尿及男性生殖系统肿瘤研究中的应用.国外医学、泌尿系统分册.1984,4:145.
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