A study on the anti-cancer drugs'sensitivity in the cancer cells and WBC of cancer's patients with MTT assay in vitro

The sensitivity of cancer cells and peripheral blood leukocytes (PBL) to 15kinds of drug were tested by the MTT method in 78 patients. The results showed that: There were not significant differences among the ten kinds of drug in the sensitivity, and the suppresive rates of cancer cells, and PBL from the patients suffered from gynecologic tumors. The differences mentioned above was parallel between cancer cells and the PBL. The similar detection was got from the pulmonarycancer's patients. The sensitivity of the PBL to CTX was obviously higherthan that of the tumous cells, but there were not significant differeences in the sensitivities of both cells to the other 9 kinds of the drug. Signific and diffierences in the sensitivity of two kinds of cell to 5-Fu, MMC, CTX and DDP were found in the patients with colon or rectal carcinoma, and the suppresive rates of cancer cells werehigher than hatt of the PBL(P＜0.001, P＜0.025).